RKIP: Much more than Raf Kinase inhibitory protein

Al-MullaF.; BitarM.S.; TaqiZ.YeungK.C.

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RKIP: Much more than Raf Kinase inhibitory protein

机译：RKIP:比Raf激酶抑制蛋白质

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From its discovery as a phosphatidylethanolamine-binding protein in bovine brain to its designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical molecule for maintaining subdued, well-orchestrated cellular responses to stimuli. The disruption of RKIP in a wide range of pathologies, including cancer, Alzheimer's disease, and pancreatitis, makes it an exciting target for individualized therapy and disease-specific interventions. This review attempts to highlight recent advances in the RKIP field underscoring its potential role as a master modulator of many pivotal intracellular signaling cascades that control cellular growth, motility, apoptosis, genomic integrity, and therapeutic resistance. Specific biological and functional niches are highlighted to focus future research towards an enhanced understanding of the multiple roles of RKIP in health and disease.

机译：作为一个从其发现phosphatidylethanolamine-binding蛋白质牛脑称号生理Raf激酶蛋白的抑制剂,RKIP已成为一个关键分子保持低调,精心组织的细胞对刺激的反应。广泛的疾病,包括癌症、阿尔茨海默病,胰腺炎,使它一个令人兴奋的个性化治疗和目标针对疾病的干预措施。RKIP试图突出最新进展领域凸显出其潜在作用的主人许多重要的细胞内信号调制器级联控制细胞增长,能动性,细胞凋亡、基因完整性和治疗阻力。利基市场强调未来的研究重点向一个增强对多个的理解RKIP的角色在健康和疾病。

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《Journal of Cellular Physiology》 |2013年第8期|1688-1702|共15页
作者
Al-MullaF.; BitarM.S.; TaqiZ.YeungK.C.;
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作者单位

Department of Biochemistry and Cancer Biology, College of Medicine, Health Science Campus;

Faculty of Medicine, Department of Pathology, Kuwait University Health Sciences Centre, Safat;

Department of Molecular Biology, College of Biological Science, University of Kuwait, Safat, KuwaitFaculty of Medicine, Department of Pharmacology, Kuwait University Health Sciences Centre, Safat;

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正文语种英语
中图分类细胞生物学;
关键词
Response to stimulus finding; Phosphatidylethanolamine Binding Protein; Pancreatitis;

机译：刺激反应发现,磷脂酰乙醇胺结合蛋白质;胰腺炎;

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机译：Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Catechin; Cell Line, Tumor; Ceramides; Drug Synergism; Enzyme Activation; Humans; Ibuprofen; Male; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53;*脱噬作用; Caspase类; 儿茶素; 神经酰胺类; 药物协同作用; 酶激活; 布洛芬; 氧化性应激; 磷酰化; 前列腺肿瘤; 原致癌基因蛋白质 c-bcl-2
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RKIP: Much more than Raf Kinase inhibitory protein

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