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首页> 外文期刊>Journal of Cellular Physiology >Functional regulation of HIF-1alpha under normoxia--is there more than post-translational regulation?
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Functional regulation of HIF-1alpha under normoxia--is there more than post-translational regulation?

机译：功能性监管下的HIF-1alphanormoxia——有超过翻译后监管?

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The hypoxia-inducible factor-1 (HIF-1) is an oxygen-regulated transcriptional activator playing a pivotal role in mammalian physiology and disease pathogenesis, e.g., HIF-1 is indispensable in a broad range of developmental stages in different tumors. Its post-translational regulation via PHDs under the influence of hypoxia is widely investigated and accepted. Different non-hypoxic stimuli such as lipopolysaccharides (LPS), thrombin, and angiotensin II (Ang II), have been proven to enhance HIF-1 levels through activation of regulative mechanisms distinct from protein stabilization. Some of these stimuli specifically regulate HIF-1alpha at the transcriptional, post-transcriptional, or translational level, whereas others additionally influence post-translational modifications. Thus, it is difficult for the investigators to discern the impact of the different mechanisms leading to functional HIF-1 protein. Nevertheless, profound knowledge of additional regulatory networks appears to depict new therapeutic opportunities and thus is an interesting and important field for further investigations.
机译：低氧诱导因子- 1 (HIF-1)是一种oxygen-regulated转录激活哺乳动物生理学中扮演关键角色和疾病的发病机制,例如,HIF-1在广泛的发展不可或缺的阶段在不同的肿瘤。通过博士在翻译后调节缺氧的影响被广泛研究接受。脂多糖(LPS)、凝血酶和血管紧张素ⅱ(Angⅱ),已经被证明通过激活增强HIF-1水平调节机制不同于蛋白质稳定。在转录调节HIF-1alpha,转录后或转化水平,而另一些另外的影响转录后修饰。研究人员很难辨别不同的机制导致的影响功能性HIF-1蛋白质。额外的监管网络的知识似乎描绘新的治疗机会因此是一个有趣的和重要的领域为进一步调查。

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