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首页> 外文期刊>Journal of Cellular Physiology >Pathophysiology of stroke and stroke-induced retinal ischemia: Emerging role of stem cells
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Pathophysiology of stroke and stroke-induced retinal ischemia: Emerging role of stem cells

机译：中风的病理生理学和stroke-induced视网膜缺血:新兴的干细胞

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摘要

The current review focuses on pathophysiology, animal models and molecular analysis of stroke and retinal ischemia, and the role of stem cells in recovery of these disease conditions. Research findings associated with ischemic stroke and retinal ischemia have been discussed, and efforts towards prevention and limiting the recurrence of ischemic diseases, as well as emerging treatment possibilities with endothelial progenitor cells (EPCs) in ischemic diseases, are presented. Although most neurological diseases are still not completely understood and reliable treatment is lacking, animal models provide a major step in validating novel therapies. Stem cell approaches constitute an emerging form of cell-based therapy to treat ischemic diseases since it is an attractive source for regenerative therapy in the ischemic diseases. In this review, we highlight the advantages and limitations of this approach with a focus on key observations from preclinical animal studies and clinical trials. Further research, especially on treatment with EPCs is warranted.
机译：此综述主要讲述了病理生理学,中风动物模型和分子分析视网膜缺血,干细胞的作用在这些疾病的恢复情况。发现与缺血性中风和讨论了视网膜缺血,努力对预防和限制的复发缺血性疾病,以及新兴的治疗与内皮祖细胞的可能性(epc)在缺血性疾病。尽管大多数神经系统疾病仍没有完全理解和可靠的治疗缺乏动物模型提供一个主要步骤验证新的治疗方法。构成一个新兴形式的细胞疗法因为它是一种治疗缺血性疾病有吸引力的来源的再生治疗缺血性疾病。这种方法的优点和局限性关注关键从临床观察动物实验和临床试验。研究,特别是在治疗内皮祖细胞必要的。

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