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首页> 外文期刊>Journal of Cellular Physiology >Epigenetics of μ-opioid receptors: Intersection with HIV-1 infection of the central nervous system
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Epigenetics of μ-opioid receptors: Intersection with HIV-1 infection of the central nervous system

机译：表观遗传学的μ阿片受体:十字路口与hiv - 1感染中枢神经系统

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摘要

The abuse of intravenous drugs, such as heroin, has become a major public health concern due to the increased risk of HIV-1 infection. Opioids such as heroin were originally identified and subsequently abused for their analgesic effects. However, many investigations have found additional effects of opioids, including regulation of the immune system. As such, chronic opioid abuse has been shown to promote HIV-1 pathogenesis and facilitate HIV-1-associated neurocognitive dysfunction. Clinical opioids, such as morphine and methadone, as well as illicit opioids, such as heroin, exert their effects primarily through interactions with the μ-opioid receptor (MOR). However, the mechanisms by which opioids enhance neurocognitive dysfunction through MOR-mediated signaling pathways are not completely understood. New findings in the regulation of MOR expression, particularly epigenetic and transcriptional regulation as well as alternative splicing, sheds new insights into possible mechanisms of HIV-1 and opiate synergy. In this review, we identify mechanisms regulating MOR expression and propose novel mechanisms by which opioids and HIV-1 may modulate this regulation. Additionally, we suggest that differential regulation of newly identified MOR isoforms by opioids and HIV-1 has functional consequence in enhancing HIV-1 neurocognitive dysfunction.
机译：静脉注射药物的滥用,如海洛因,已经成为一个主要公共卫生问题由于hiv - 1感染的风险增加。如最初识别和海洛因随后滥用镇痛效果。然而,许多调查发现额外的阿片类药物的影响,包括调节免疫系统。阿片类药物滥用已经被证明可以促进hiv - 1发病机制和促进HIV-1-associated神经认知功能障碍。如吗啡、美沙酮,以及非法阿片类药物如海洛因,发挥他们的主要通过相互作用与影响μ阿片受体(铁道部)。阿片类药物增强神经认知功能障碍通过MOR-mediated信号路径不是完全理解。发现在铁道部的规定表达,尤其是表观基因和转录监管以及可变剪接,棚屋新见解hiv - 1的可能机制和鸦片的协同作用。铁道部表达和提出的调节机制小说阿片类药物和hiv - 1可能的机制调节这一规定。建议新微分调节铁道部阿片类药物和hiv - 1亚型的识别功能结果提高hiv - 1神经认知功能障碍。

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