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首页> 外文期刊>Journal of Cellular Physiology >The requirement for proteomics to unravel stem cell regulatory mechanisms.
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The requirement for proteomics to unravel stem cell regulatory mechanisms.

机译：要求解开干细胞蛋白质组学细胞调节机制。

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摘要

Stem cells are defined by their ability to self-renew and to differentiate, the processes whereby these events are achieved is the subject of much investigation. These studies include cancer stem cell populations, where eradication of this specific population is the ultimate goal of treatment. Whilst cellular signalling events and transcription factor complex-mediated changes in gene expression have been analysed in some detail within stem cells, full systematic understanding of the events promoting self-renewal or the commitment process leading to formation of a specific cell type require a systems biology approach. This in turn demands a need for proteomic analysis of post-translational regulation of protein levels, protein interactions, protein post-translational modification (e.g. ubiquitination, methylation, acetylation, phosphorylation) to identify networks for stem cell regulation. Furthermore, the phenomenon of induced pluripotency via cellular reprogramming also can be understood optimally using combined molecular biology and proteomics approaches; here we describe current research employing proteomics and mass spectrometry to dissect stem cell regulatory mechanisms.
机译：干细胞是由他们的能力自我更新和分化的过程将这些事件实现的调查。癌症干细胞数量,根除这个特定的人口是终极目标的治疗。和转录因子complex-mediated变化在一些基因表达进行了分析细节在干细胞中,完整的系统促进理解的事件自我更新过程导致或承诺形成特定的细胞类型要求系统生物学的方法。翻译后的蛋白质组学分析的必要性调节蛋白质含量、蛋白质相互作用、蛋白质翻译后修改(如泛素化、甲基化、乙酰化、磷酸化)来识别网络对干细胞的监管。通过诱导多能性的现象细胞重新编程也可以理解使用分子生物学和优化蛋白质组学方法;研究采用蛋白质组学和质量谱分析干细胞监管机制。

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