Protein acetylation within the cellular response to radiation.

Averbeck NB; Durante M

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Protein acetylation within the cellular response to radiation.

机译：细胞内蛋白质乙酰化反应辐射。

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Post-translational protein modification represents a fundamental tool within the control of protein functions. While phosphorylation is the longest known of these modifications, several more were identified. Among these, acetylation was originally discovered as an important modification of histones within the process of transcription. Later it was revealed that histone acetylation also plays a crucial role in DNA repair, and that histones are not the only target for transient acetylation within these processes. Although there is no doubt that protein acetylation is essential, its function and even more its regulation is still not fully elucidated. Here we will discuss how protein acetylation occurs within the cellular response to radiation, a well characterized DNA-damaging environmental stressor and further want to draw the attention to open questions within the field of protein acetylation.

机译：翻译后的蛋白质修饰代表在控制蛋白质的一个基本工具功能。知道这些修改,更多识别。最初作为一个重要的发现修改组蛋白的过程转录。乙酰化作用在DNA也起着至关重要的作用修复,组蛋白并不是唯一的目标在这些过程中瞬态乙酰化作用。尽管毫无疑问,蛋白质乙酰化作用是至关重要的,它的功能,甚至更多的监管还不充分阐明。乙酰化作用发生在细胞反应辐射,能损伤dna的特征环境压力,进一步想画领域内的开放问题的关注蛋白质乙酰化作用。

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来源
《Journal of Cellular Physiology》 |2011年第4期|962-967|共6页
作者
Averbeck NB; Durante M;
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作者单位

Department of Biophysics, GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt, Germany.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
cellular effects of radiation; DNA Repair; environmental stressorHistonesPost-Translational Protein ProcessingHistone AcetylationACETYLATION;

机译：手机辐射的影响;DNA环境修复;stressorHistonesPost-Translational蛋白质ProcessingHistone AcetylationACETYLATION;

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Protein acetylation within the cellular response to radiation.

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