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首页> 外文期刊>Journal of Cellular Physiology >PINCH: More than just an adaptor protein in cellular response.
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PINCH: More than just an adaptor protein in cellular response.

机译：捏:不仅仅是一个适配器蛋白质细胞的反应。

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Particularly interesting new cysteine-histidine-rich protein (PINCH) is a LIM-domain-only adaptor protein involved in protein recruitment, subsequent assembly of multi-protein complexes, and subcellular localization of these complexes. PINCH is developmentally regulated and its expression is critical for proper cytoskeletal organization and extracellular matrix adhesion. Although PINCH has no catalytic abilities, the PIP (PINCH-ILK-parvin) complex serves as a link between integrins and components of growth factor receptor kinase and GTPase signaling pathways. Accordingly, PINCH-mediated signaling induces cell migration, spreading, and survival. Further research on the signaling cascades affected by PINCH is key to appreciating its biological significance in cell fate and systems maintenance, as the developmental functions of PINCH may extend to disease states and the cellular response to damage. PINCH is implicated in a diverse array of diseases including renal failure, cardiomyopathy, nervous system degeneration and demyelination, and tumorigenesis. This review presents evidence for PINCH's structural and functional importance in normal cellular processes and in pathogenesis. The current data for PINCH expression in nervous system disease is substantial, but due to the complex and ubiquitous nature of this protein, our understanding of its function in pathology remains unclear. In this review, an overview of studies identifying PINCH binding partners, their molecular interactions, and the potentially overlapping role(s) of PINCH in cancer and in nervous system diseases will be discussed. Many questions remain regarding PINCH's role in cells. What induces cell-specific PINCH expression? How does PINCH expression contribute to cell fate in the central nervous system? More broadly, is PINCH expression in disease a good thing? Clarifying the ambiguous functions of PINCH expression in the central nervous system and other systems is important to understand more clearly signaling events both in health and disease.
机译：特别有趣的新cysteine-histidine-rich蛋白质(压力)是一个LIM-domain-only适配器蛋白质参与蛋白质招聘,后续装配多蛋白复合物和亚细胞这些复合物的本地化。发育调控及其表达式适当的细胞骨架组织的关键细胞外基质粘附。没有催化能力,皮普作为一个链接(PINCH-ILK-parvin)复杂整合蛋白和生长因子的组成部分受体激酶GTPase信号通路。因此,PINCH-mediated信号诱导细胞迁移、扩散和生存。研究信号级联的影响捏是欣赏其生物的关键在细胞命运和意义系统维护、发展的功能压力可能扩展到疾病状态和破坏细胞反应。在一个不同的疾病,包括肾失败,心肌病,神经系统变性和髓鞘脱失,肿瘤发生。的结构和功能的重要性正常的细胞过程和发病机理。当前数据在紧张压力表达式系统疾病是很大的,但由于这种蛋白质的复杂和无处不在的性质,我们在病理的了解它的功能仍不清楚。研究确定捏约束力的合作伙伴,他们的分子相互作用和潜在的重叠的角色(s)在癌症和捏神经系统疾病将讨论。关于捏在细胞中的作用仍是个问题。诱导特异性捏表达什么?压力表达式有助于细胞的命运吗中枢神经系统?捏表达疾病是一件好事吗?澄清模糊函数的压力表达在中枢神经系统其他系统的了解是很重要的在健康和清晰的信号事件疾病。

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