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首页> 外文期刊>Journal of Cellular Physiology >The inhibitory effect of ginsan on TGF-beta mediated fibrotic process.
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The inhibitory effect of ginsan on TGF-beta mediated fibrotic process.

机译：鉴定及ginsan的抑制效果介导的纤维化过程。

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摘要

Transforming growth factor-beta (TGF-beta) plays a central role in the development of fibrosis by stimulating extracellular matrix accumulation, and signals either directly or indirectly through types I, II, and III (TbetaRI, II, and III) TGF-beta receptor complexes. Ginsan, a polysaccharide extracted from Panax ginseng, has multiple immunomodulatory effects. Here, we examine whether ginsan regulates the fibrogenic process by interfering with TGF-beta signaling pathways. TGF-beta treatment of murine or human normal lung fibroblasts enhanced the levels of several fibrotic markers, including smooth muscle alpha actin (alpha-SMA), collagen-1, and fibronectin. Interestingly, ginsan treatment either before or after TGF-beta administration led to significant reductions in all of alpha-SMA, collagen-1, and fibronectin expression levels. Ginsan not only inhibited phosphorylation of Smad2 and Smad3, but also attenuated pERK and pAKT signaling induced by TGF-beta. Moreover, ginsan restored TbetaRIII protein expression, which was significantly downregulated by TGF-beta, but reduced TbetaRI and TbetaRII protein levels. In a murine model of bleomycin (BLM)-induced pulmonary fibrosis, ginsan significantly suppressed accumulation of collagen, alpha-SMA, and TGF-beta. These data collectively suggest that ginsan acts as an effective anti-fibrotic agent in the treatment of pulmonary fibrosis by blocking multiple TGF-beta signaling pathways.
机译：转化生长因子(及)扮演核心作用在纤维化的发展刺激细胞外基质堆积,和信号直接或间接通过类型I, II, III (TbetaRI、II和III)鉴定及受体复合物。从人参中提取的多糖,多种免疫调节作用。检查是否ginsan调节纤维发生的通过干扰及信号传导过程通路。正常的肺成纤维细胞的水平提高几个纤维化的标记,包括平滑肌α肌动蛋白(alpha-SMA), collagen-1,纤连蛋白。之前或之后鉴定及管理导致所有的显著减少alpha-SMA collagen-1,纤连蛋白表达的水平。Smad2和Smad3,还减振作pAKT信号及引起的。ginsan恢复TbetaRIII蛋白表达,大幅下调的吗及,但减少TbetaRI和TbetaRII蛋白质的水平。(BLM)全身的肺纤维化,ginsan显著抑制积累胶原蛋白、alpha-SMA,及护。集体建议ginsan充当有效的anti-fibrotic剂治疗多个及肺纤维化通过阻断信号通路。

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