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首页> 外文期刊>Journal of Cellular Physiology >Complexity of polycomb group function: diverse mechanisms of target specificity.
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Complexity of polycomb group function: diverse mechanisms of target specificity.

机译：的复杂性polycomb组功能:多样化目标特异性的机制。

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摘要

Epigenetic regulation of gene expression has become relevant to nearly all areas of biomedical research. The emergence of technologies that allow for examination of the epigenome combined with identification of key protein complexes that mediate the myriad chromatin modifications that occur have greatly enhanced the versatility and efficacy of tools with which to study normal development and disease states. The evolutionarily conserved polycomb group genes (PcG) have been identified as a predominant mechanism by which gene silencing occurs during development, differentiation, and disease. While molecular events that target PcG complexes have been well defined in some non-vertebrate models, the details of locus specificity and functional diversity of mammalian PcG proteins have not yet unresolved. Here we discuss recent findings that offer novel mechanistic events and add complexity to our understanding of PcG function in vertebrates.
机译：表观遗传调控基因的表达成为生物医学相关的几乎所有领域研究。允许考试的表观基因组的总和识别关键蛋白复合物调解的无数染色质的修改大大提高了通用性和发生功效的工具来研究正常发展和疾病状态。进化保守polycomb组基因(PcG)已确定为主导基因沉默的机制发生在开发、分化和疾病。目标PcG复合物分子事件在一些non-vertebrate模型定义良好的,位点特异性和功能的细节哺乳动物的多样性PcG蛋白质尚未没有解决。提供新颖的机械活动,增加了复杂性我们对你们的理解函数脊椎动物。

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