Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling.

Singh SR; Zheng Z; Wang HOh SWChen XHou SX

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Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling.

机译：利基和相互竞争力生殖系干细胞和体细胞的依赖在果蝇睾丸的监管

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In many tissues, two or more types of stem cells share a niche, and how the stem cells coordinate their self-renewal and differentiation is poorly understood. In the Drosophila testis, germ line stem cells (GSCs) and somatic cyst progenitor cells (CPCs) contact each other and share a niche (the hub). The hub expresses a growth factor unpaired (Upd) that activates the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway in GSCs to regulate the stem cell self-renewal. Here, we demonstrate that the JAK/STAT signaling also regulates CPCs self-renewal. We also show that a negative regulator, the suppressor of cytokine signaling 36E (SOCS36E), suppresses JAK/STAT signaling in somatic cells, preventing them from out-competing the GSCs. Furthermore, through selectively manipulating the JAK/STAT signaling level in either CPCs or GSCs, we demonstrate that the somatic JAK/STAT signaling is essential for self-renewal and maintenance of both CPCs and GSCs. These data suggest that a single JAK/STAT signal from the niche orchestrate the competitive and dependent co-existence of GSCs and CPCs in the Drosophila testis niche.

机译：在许多组织中,两个或更多类型的干细胞分享一个利基,干细胞如何协调他们的自我更新和分化差理解。干细胞(gsc)和体细胞囊肿祖细胞(年度"特别关注国")相互联系和分享一个利基(中心)。未配对(乌利希期刊指南),激活杰纳斯激酶/信号传感器和催化剂转录(JAK / STAT) gsc的途径调节干细胞自我更新。也表明,JAK / STAT信号调节年度"特别关注国"自我更新。消极的调节器,细胞因子的抑制信号36 e (SOCS36E),抑制JAK / STAT信号在体细胞,阻止他们将gsc体型。选择性地操纵JAK / STAT信号在年度"特别关注国"或gsc水平,我们证明体细胞JAK / STAT信号是至关重要的确定特别关注国和自我更新和维护gsc。信号从利基编排的竞争和依赖共存的gsc和年度"特别关注国"果蝇睾丸利基。

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来源
《Journal of Cellular Physiology》 |2010年第2期|500-510|共11页
作者
Singh SR; Zheng Z; Wang HOh SWChen XHou SX;
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作者单位

Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.;

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正文语种英语
中图分类细胞生物学;
关键词
Stem Cells; niches; germ lineAdult Stem CellsCompetitivenessSignal TransductionTestisDrosophilaSuppressor of Cytokine Signaling ProteinsRenewalELAVL2 geneHUB;

机译：干细胞;利基市场;生殖lineAdult茎CellsCompetitivenessSignalTransductionTestisDrosophilaSuppressor的;

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1. JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila [J] . Shree Ram SINGH, Xiu CHEN, Steven X.HOU 细胞研究（英文版） . 2005,第001期
2. discs large regulates somatic cyst cell survival and expansion in Drosophila testis [J] . Fani Papagiannouli, Bernard M Mechler 细胞研究：英文版 . 2009,第010期
3. discs large regulates somatic cyst cell survival and expansion in Drosophila testis [J] . Fani Papagiannouli, Bernard M Mechler 细胞研究（英文版） . 2009,第010期
4. Researchers Identify a Novel Mechanism That Regulates Germline Stem Cell Function in Drosophila [J] . CHEN Dahua 中国科学院院刊（英文版） . 2017,第002期

Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling.

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