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首页> 外文期刊>Journal of Cellular Physiology >Meiotic cell cycle arrest in mammalian oocytes
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Meiotic cell cycle arrest in mammalian oocytes

机译：在哺乳动物卵母细胞减数分裂的细胞周期阻滞

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摘要

Meiotic cell cycle in mammalian oocytes is a dynamic process that involves several stop/go channels. The cell cycle arrest in oocyte occurs at various stages such as diplotene, metaphase-I (M-I), metaphase-II (M-II), and so called metaphase-like arrest (M-III). Leutinizing hormone surge induces meiotic resumption from diplotene arrest in follicular microenvironment by over-riding several factors responsible for the maintenance of meiotic arrest. The inhibitory factors are synthesized in oocyte or in the associated follicular somatic cells and transferred to the oocyte. The major factors include hypoxanthine, cyclic adenosine 3′, 5′-monophosphate, cyclic guanosine 3′, 5′-monophosphate, reactive oxygen species, protein kinase A, and protein kinase C. In the presence of active protein kinases, epidermal-like growth factors are produced that activate mitogen-activated protein kinase in cumulus granulosa cells. The maturation promoting factor, cytostatic factors, and spindle assembly checkpoint proteins are also involved in the maintenance of arrest at various stages of meiotic cell cycle in mammalian oocytes. In this review, we briefly summarize the role of these factors in the maintenance of meiotic cell cycle arrest in mammalian oocytes.
机译：在哺乳动物卵母细胞减数分裂的细胞周期动态过程,涉及到几个停止/走频道。在双线期等不同阶段,中期i(m i),中期ii (M-II),和所谓的metaphase-like逮捕(M-III)。激素激增引发减数分裂恢复双线期卵泡微环境中被逮捕的最重要的几个因素负责减数分裂逮捕的维护。因素在卵母细胞或合成卵泡体细胞和有关转移到卵母细胞。包括次黄嘌呤,环腺3 ',环鸟苷3 ',5 '一磷酸5 '一磷酸,活性氧,蛋白激酶和蛋白激酶c活性蛋白激酶,epidermal-like生长因子产生激活增殖蛋白激酶积云颗粒细胞。因素,抑制细胞生长的因素,主轴总成检查点的蛋白质也参与了逮捕在不同阶段的维护在哺乳动物卵母细胞减数分裂的细胞周期。审查,我们简要总结的作用因素在减数分裂细胞周期的维护逮捕在哺乳动物卵母细胞。

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