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首页> 外文期刊>Journal of Cellular Physiology >Assembling heterochromatin in the appropriate places: A boost is needed.
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Assembling heterochromatin in the appropriate places: A boost is needed.

机译：在适当的组装异染色质地方:增加是必要的。

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摘要

Heterochromatin, or condensed chromatin, has the potential to encroach into what ordinarily would be euchromatin and repress resident genes. We explore how heterochromatin is restricted to the appropriate regions of the genome, using Saccharomyces cerevisiae as a case study and emphasizing two under-appreciated aspects of silenced chromatin. First, the capacity of silenced chromatin to propagate along a chromosome is limited by the intrinsic instability of the structure. We argue that this limited potential to spread is an important factor restricting silenced chromatin to the vicinity of recruitment sites (silencers). Second, this limited capacity to spread creates the need for additional mechanisms to stabilize silenced chromatin at the required locations. Such mechanisms include the use of multiple silencers and higher-order arrangements of the chromatin fiber. Therefore, to understand how silenced chromatin is restricted to the appropriate genomic locations, researchers must take into account the mechanisms by which silenced chromatin is stabilized in appropriate locations. J. Cell. Physiol. 219: 525-528, 2009. (c) 2009 Wiley-Liss, Inc.
机译：或染色质凝集,异染色质可能侵犯到通常会做什么常染色质和抑制居民的基因。探索如何限制到异染色质适当的的基因组区域,使用酿酒酵母作为一个案例研究强调两个最被忽视的方面沉默染色质。沿着一个沉默染色质传播内在的染色体是有限的不稳定的结构。有限的可能是一个重要的传播沉默染色质的限制因素附近的招聘网站(消音器)。第二,这个能力有限传播创建需要额外的机制来稳定沉默染色质在所需的位置。这些机制包括使用多个消音器和高阶的安排染色质纤维。沉默染色质是受限制的适当的基因位点,研究人员必须考虑的机制沉默染色质在适当的稳定的位置。(c) 2009年Wiley-Liss公司。

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