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首页> 外文期刊>Journal of Cellular Physiology >Pluripotency: toward a gold standard for human ES and iPS cells.
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Pluripotency: toward a gold standard for human ES and iPS cells.

机译：多能性:对人类ES的黄金标准和“诱导多能性”细胞。

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摘要

With the advent of technologies for the derivation of embryonic stem cells and reprogrammed stem cells, use of the term "pluripotent" has become widespread. Despite its increased scientific and political importance, there are ambiguities with this designation and a common standard for experimental approaches that precisely define this state in human cells remains elusive. Recent studies have revealed that reprogramming may occur via many pathways which do not always lead to pluripotency. In addition, the pluripotent state itself appears to be highly dynamic, leading to significant variability in the results of molecular studies. Establishment of a stringent set of criteria for defining pluripotency will be vital for biological studies and potential clinical applications in this rapidly evolving field. In this review, we explore the various definitions of pluripotency, examine the current status of pluripotency testing in the field and provide an analysis of how these assays have been used to establish pluripotency in the scientific literature.
机译：随着技术的推导胚胎干细胞和干细胞重新编程细胞,使用术语“多能”普遍。政治重要性,有歧义这个名称和一个共同的标准实验方法,精确定义在人类细胞中这种状态仍然是难以捉摸的。研究表明,重组通过许多途径并不总是发生多能性。国家本身似乎是高度动态的,导致显著变化的结果分子的研究。严格的标准定义多能性将为生物研究是至关重要的和潜在的临床应用快速发展的领域。探索各种多能性的定义,检查多能性的当前状态测试领域和提供了一个分析这些化验已经被用于建立如何多能性的科学文献。

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