Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells.

Cascio S; Ferla R; DAndrea A

首页> 外文期刊>Journal of Cellular Physiology >Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells.

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Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells.

机译：表达血管生成的监管机构、VEGF和瘦素是由EGF / PI3K / STAT3在结直肠癌细胞通路。

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Both leptin and vascular endothelial growth factor (VEGF) are growth and angiogenic cytokines that are upregulated in different types of cancer and have been implicated in neoplastic progression. Here we investigated the molecular mechanism by which leptin and VEGF expression are regulated in colon cancer by epidermal growth factor (EGF). In colon cancer cell line HT-29, EGF induced the binding of signal transducer and activator transcription 3 (STAT3) to STAT3 consensus motifs within the VEGF and leptin promoters and stimulated leptin and VEGF mRNA and protein synthesis. All these EGF effects were significantly blocked when HT-29 cells were treated with an inhibitor of the phosphoinositide 3-kinase (PI3K) pathway, LY294002, or with small interfering RNA (siRNA) targeting STAT3. Thus, our study identified the EGF/PI3K/STAT3 signaling as an essential pathway regulating VEGF and leptin expression in EGF-responsive colon cancer cells. This suggests that STAT3 pathways might constitute attractive pharmaceutical targets in colon cancer patients where anti-EGF receptor drugs are ineffective.

机译：瘦素和血管内皮生长因子生长和血管生成细胞因子(VEGF)不同类型的癌症和调节吗与肿瘤进展。在这里,我们调查的分子机制瘦素和VEGF表达的监管结肠癌的表皮生长因子(EGF)。结肠癌细胞系HT-29, EGF诱导结合信号传感器和催化剂转录(STAT3 STAT3共识度)3理由VEGF和瘦素启动子瘦素和刺激VEGF mRNA和蛋白合成。当HT-29细胞明显受阻处理的抑制剂磷酸肌醇3-kinase PI3K通路,LY294002或小interfering RNA(消失)targeting STAT3。我们的研究发现EGF / PI3K / STAT3信号作为一个调节VEGF和基本途径瘦素表达EGF-responsive结肠癌细胞。构成吸引力的药物目标结肠癌患者anti-EGF受体药物是无效的。

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来源
《Journal of Cellular Physiology》 |2009年第1期|189-194|共6页
作者
Cascio S; Ferla R; DAndrea A;
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作者单位

Department of Surgical and Oncological Sciences, Section of Medical Oncology, Universita di Palermo, Palermo, Italy.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Cancer of Colon; cancer cell; colon cancer cell lineVascular Endothelial Growth Factor Asignal transducerPathwayEGF Family of ProteinsLeptinAngiogenesis;

机译：结肠癌症,癌细胞;结肠癌细胞Asignal lineVascular内皮生长因子transducerPathwayEGF家族ProteinsLeptinAngiogenesis;

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Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells.

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