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首页> 外文期刊>Journal of Cellular Physiology >Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury.
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Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury.

机译：巨噬细胞之间的相互作用、TGF-beta1和cox - 2通路在炎症阶段的骨骼肌损伤后愈合。

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摘要

Inflammation, an important phase of skeletal muscle healing, largely involves macrophages, TGF-beta1, and the COX-2 pathway. To improve our understanding of how these molecules interact during all phases of muscle healing, we examined their roles in muscle cells in vitro and in vivo. Initially, we found that depletion of macrophages in muscle tissue led to reduced muscle regeneration. Macrophages may influence healing by inducing the production of TGF-beta1 and PGE2 in different muscle cell types. We then found that the addition of TGF-beta1 induced PGE2 production in muscle cells, an effect probably mediated by COX-2 enzyme. It was also found that TGF-beta1 enhanced macrophage infiltration in wild-type mice after muscle injury. However, this effect was not observed in COX-2(-/-) mice, suggesting that the effect of TGF-beta1 on macrophage infiltration is mediated by the COX-2 pathway. Furthermore, we found that PGE2 can inhibit the expression of TGF-beta1. PGE2 and TGF-beta1 may be involved in a negative feedback loop balancing the level of fibrosis formation during skeletal muscle healing. In conclusion, our results suggest a complex regulatory mechanism of skeletal muscle healing. Macrophages, TGF-beta1, and the COX-2 pathway products may regulate one another's levels and have profound influence on the whole muscle healing process.
机译：炎症,骨骼的一个重要阶段肌肉愈合,主要包括巨噬细胞、TGF-beta1, cox - 2通路。对这些分子如何相互作用的理解在所有阶段的肌肉愈合,我们检查了他们的角色在肌肉细胞在体外和体内。最初,我们发现巨噬细胞的损耗肌肉组织导致减少肌肉再生。通过诱导TGF-beta1和PGE2的生产在不同的肌细胞类型。TGF-beta1诱导PGE2的加法生产在肌肉细胞,可能产生影响由cox - 2酶。TGF-beta1增强巨噬细胞浸润野生型老鼠后肌肉损伤。效果没有观察到cox - 2(- / -)小鼠,这表明TGF-beta1的效果cox - 2介导的巨噬细胞浸润途径。抑制TGF-beta1的表达。TGF-beta1可能参与一个负面的反馈循环平衡纤维化形成的水平在骨骼肌愈合。我们的结果显示一个复杂的监管骨骼肌愈合机制。巨噬细胞、TGF-beta1和cox - 2通路产品可能调节彼此的水平对整个肌肉有深远的影响愈合过程。

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