The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness.

Wolf M; Nunes F; Henkel AHeinick APaul RJ

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The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness.

机译：秀丽隐杆线虫的MAP激酶JNK-1:位置、激活和影响与温度有关的胰岛素样信号,压力反应,和健身。

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The mitogen-activated protein kinase (MAPK) pathways and insulin-like signaling play pivotal roles in cellular stress response. Using an anti-phospho-SAPK/JNK antibody and a daf-16::GFP-based reporter assay, the present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16, the main downstream target of insulin-like signaling. Activated JNK-1 was detected only in neuronal cells, and JNK-1 was found to be controlled by the MAPK JKK-1 under heat stress. Comparative analyses on the wildtype and a jnk-1 deletion mutant revealed a promoting influence of JNK-1 on both nuclear DAF-16 translocations and DAF-16 target gene (superoxide dismutase 3, sod-3) expressions within peripheral, non-neuronal tissue. Consequently, the mutant exhibited a reduced thermal tolerance and reproductive fitness at higher temperatures. These results provide evidence of indirect interactions between neuronal MAPK and peripheral insulin-like signaling in response to environmental stimuli (temperature, H2O2).

机译：增殖作用的蛋白激酶(MAPK)胰岛素样信号转导途径和关键角色在细胞应激反应。anti-phospho-SAPK /物抗体和daf-16:: GFP-based记者分析,目前研究显示在秀丽隐杆线虫环境温度(1-37摄氏度)激活(磷酸化)的影响MAP激酶JNK-1以及核DAF-16易位,主要下游胰岛素样信号的目标。只发现在神经元细胞,JNK-1吗被发现控制的MAPK JKK-1吗在热应力。野生型和jnk-1缺失突变体显示促进JNK-1两核的影响DAF-16易位和DAF-16目标基因(超氧化物歧化酶sod-3)表达式在外围,non-neuronal组织。因此,突变体表现出减少热宽容和生殖健康更高的温度。间接的证据之间的相互作用神经元MAPK和外周胰岛素样信号以响应环境刺激(温度、过氧化氢)。

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来源
《Journal of Cellular Physiology》 |2008年第3期|721-729|共9页
作者
Wolf M; Nunes F; Henkel AHeinick APaul RJ;
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作者单位

Institut fur Zoophysiologie, Westfalische Wilhelms-Universitat Munster, Munster, Germany.;

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正文语种英语
中图分类细胞生物学;
关键词
Signal Transduction; Deletion mutant; healthCellular Stress ResponseCaenorhabditis elegansstress responseCaenorhabditis elegans ProteinsReproductive FitnessCell nucleusMitogen-Activated Protein KinasesNuclear TranslocationNucleus;

机译：信号转导;缺失突变;healthCellular压力ResponseCaenorhabditis elegansstressresponseCaenorhabditis秀丽隐杆线虫ProteinsReproductive FitnessCellnucleusMitogen-Activated蛋白质KinasesNuclearTranslocationNucleus;

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The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness.

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