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首页> 外文期刊>Journal of Cellular Physiology >Effect of transforming viruses on molecular mechanisms associated with cancer.
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Effect of transforming viruses on molecular mechanisms associated with cancer.

机译：改变病毒分子的影响机制与癌症有关。

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摘要

Viruses have been linked to approximately 20% of all human tumors worldwide. These transforming viruses encode viral oncoproteins that interact with cellular proteins to enhance viral replication. The transcriptional and post-transcriptional effects of these viral oncoproteins ultimately result in cellular transformation. Historically, viral research has been vital to the discovery of oncogenes and tumor suppressors with more current research aiding in unraveling some mechanisms of carcinogenesis. Interestingly, since transforming viruses affect some of the same pathways that are dysregulated in human cancers, their study enhances our understanding of the multistep process of tumorigenesis. This review will examine the cellular mechanisms targeted by oncogenic human viruses and the processes by which these effects contribute to transformation. In particular, we will focus on three transforming viruses, human T-cell leukemia virus type-I, hepatitis B virus and human papillomavirus. These viruses all encode specific oncogenes that promote cell cycle progression, inhibit DNA damage checkpoint responses and prevent programmed cell death in an effort to promote viral propagation. While the transforming properties of these viruses are probably unintended consequences of replication strategies, they provide excellent systems in which to study cancer development.
机译：与大约20%的病毒全世界所有人类肿瘤。病毒编码病毒癌基因蛋白相互作用与细胞蛋白增强病毒复制。这些病毒转录后的影响癌基因蛋白最终导致细胞转换。对致癌基因的发现和是至关重要的肿瘤抑制更多的研究现状协助解开一些机制致癌作用。病毒影响一些相同的途径在人类癌症特异表达,他们的研究提高我们对多步的理解肿瘤发生的过程。检查细胞机制的目标人类致癌病毒和过程这些影响导致转换。特别是,我们将把重点放在三个改变病毒、人类t细胞白血病病毒i型、B型肝炎病毒和人类乳头状瘤病毒。致癌基因,促进细胞周期进程,抑制DNA损伤检查点和反应防止细胞程序性死亡,以促进病毒传播。这些病毒可能的属性意想不到的后果的复制策略,他们提供优秀的系统研究癌症发展。

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