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首页> 外文期刊>Current drug research reviews. >Significance of 1,3,4-Oxadiazole Containing Compounds in New Drug Development
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Significance of 1,3,4-Oxadiazole Containing Compounds in New Drug Development

机译：意义1、3,则对包含化合物在新药开发

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Background: Oxadiazole core displays various pharmacological properties among five membered nitrogen heterocyclic compounds, specially 1,3,4-oxadiazole containing molecules that have occupied a particular place in the field of synthetic medicinal chemistry as surrogates (bioi-sosteres) of carboxylic acids, carboxamides and esters. Moreover, they are having widespread kind of applications in numerous zones as polymers, as luminescence producing materials and as electron-transporting materials and corrosion inhibitors. Methods: This study contains comprehensive and extensive literature survey on chemical reactivity and biological properties associated with 1,3,4-oxadiazole containing compounds. Results: This review summarises 1,3,4-oxadiazole moiety in numerous compounds with reported pharmacological activity such as antiviral, analgesic and anti-inflammatory, antitumor, antioxidant, insecticidal and anti-parasitic, etc. Nevertheless, ring opening reactions of the 1,3,4-oxadiazole core have also made great attention, as they produce new analogues containing an aliphatic nitrogen atom and to other ring systems. Conclusion: In relation to the occurrence of oxadiazoles in biologically active molecules, 1,3,4-oxadiazole core emerges as a structural subunit of countless significance and usefulness for the development of new drug aspirants applicable to the treatment of many diseases. It concludes that 1,3,4-oxadiazole core compounds are more efficacious and less toxic medicinal agents with respect to new opinions in the search for rational strategies.
机译：背景:Oxadiazole核心显示不同药理属性中五元氮杂环化合物,特别是1, 3,则对包含分子占领一个特定领域的合成药物化学作为替代(bioi-sosteres)羧酸酰胺和酯类。应用程序在许多区域聚合物发光材料和生产作为电子传输材料和腐蚀抑制剂。全面的和广泛的文献调查化学反应和生物属性1, 3,则对包含化合物。在很多化合物1,3,则对一半与报告等药理作用抗病毒、镇痛和抗炎,抗肿瘤,抗氧化,杀虫寄生虫等。反应的1、3,则对核心也取得了巨大的关注,产生新的类似物含有脂肪族氮原子和其他环系统。恶二唑的发生有关生物活性分子,1,3,则对无数的核心出现作为一个结构单元发展的意义和作用适用于治疗的新药的候选国许多疾病。1、3,则对核心化合物更有效的和更少的有毒药用制剂关于寻找的新观点理性的策略。

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