...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current drug research reviews. >Drug Repurposing: An Emerging Tool for Drug Reuse, Recycling and Discovery
【24h】

Drug Repurposing: An Emerging Tool for Drug Reuse, Recycling and Discovery

机译：药物药物重定位:一个新兴工具重用,回收和发现

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Drug repositioning or repurposing is a revolutionary breakthrough in drug development that focuses on rediscovering new uses for old therapeutic agents. Drug repositioning can be defined more precisely as the process of exploring new indications for an already approved drug while drug repurposing includes overall re-development approaches grounded in the identical chemical structure of the active drug moiety as in the original product. The repositioning approach accelerates the drug development process, curtails the cost and risk inherent to drug development. The strategy focuses on the polypharmacology of drugs to unlocks novel opportunities for logically designing more efficient therapeutic agents for unmet medical disorders. Drug repositioning also expresses certain regulatory challenges that hamper its further utilization. The review outlines the eminent role of drug repositioning in new drug discovery, methods to predict the molecular targets of a drug molecule, advantages that the strategy offers to the pharmaceutical industries, explaining how the industrial collaborations with academics can assist in the discovering more repositioning opportunities. The focus of the review is to highlight the latest applications of drug repositioning in various disorders. The review also includes a comparison of old and new therapeutic uses of repur-posed drugs, assessing their novel mechanisms of action and pharmacological effects in the management of various disorders. Various restrictions and challenges that repurposed drugs come across during their development and regulatory phases are also highlighted.
机译：药物重新定位或再利用在药物开发革命性的突破重点重新发现新用途治疗药物。更精确地定义为的过程探索新的适应症已经批准药物在药物再利用包括整体发展的方法相同的化学结构的有效药物一半的原始产品。重新定位的方法加快了药物开发过程,可以减少成本和风险固有的药物开发。关注的polypharmacology药物解锁逻辑的新机会设计更有效的治疗药物未满足的医疗疾病。表达一定的监管挑战阻碍其进一步的利用。概述了药物的著名角色重新定位在新药发现、预测方法分子靶点的药物分子,优势这一策略提供制药行业,说明工业与学者的合作可以协助发现更多的重新定位机会。审查的重点是突出最新的药物重新定位在不同的应用程序障碍。旧的和新的治疗repur-posed的使用药物,评估他们小说的作用机制和管理的药理作用各种各样的疾病。特制药物遇到挑战在开发和管理阶段也会高亮显示。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号