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首页> 外文期刊>Journal of Cellular Physiology >The TFG protein, involved in oncogenic rearrangements, interacts with TANK and NEMO, two proteins involved in the NF-kappaB pathway.
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The TFG protein, involved in oncogenic rearrangements, interacts with TANK and NEMO, two proteins involved in the NF-kappaB pathway.

机译：过渡政府蛋白质,参与致癌重组,与水箱和尼莫,两个蛋白质参与NF-kappaB通路。

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摘要

TRK-fused gene (TFG) was first identified as a partner of NTRK1 in generating the thyroid TRK-T3 oncogene, and is also involved in oncogenic rearrangements with ALK in anaplastic lymphoma and NOR1 in mixoid chondrosarcoma. The TFG physiological role is still unknown, but the presence of a number of motifs involved in protein interactions suggests that it may function by associating with other proteins. We have recently demonstrated that TFG associates and regulates the activity of the tyrosine phosphatase SHP-1. In this study by yeast two-hybrid screening we identified NEMO and TANK, two proteins modulating the NF-kappaB pathway, as novel TFG-interacting proteins. These interactions were further characterized in vitro and in vivo. We provide evidence that TFG and NEMO may be part of the same high molecular weight complex. TFG enhances the effect of TNF-alpha, TANK, TNF receptor-associated factor (TRAF)2, and TRAF6 in inducing NF-kappaB activity. We suggest that TFG is a novel member of the NF-kappaB pathway.
机译：TRK-fused基因(过渡政府)是首次发现在生成甲状腺TRK-T3 NTRK1伙伴癌基因,也参与致癌重组与碱在间变性淋巴瘤和NOR1 mixoid软骨肉瘤。生理作用仍然是未知的,但是存在许多主题参与蛋白质相互作用表明它可能与其他蛋白质函数相关联。最近表明,过渡政府的同事吗和调节酪氨酸的活动磷酸酶SHP-1。二者混合筛选我们确定了尼莫和坦克,两种蛋白质调节NF-kappaB通路,小说TFG-interacting蛋白质。进一步体外特征的交互和体内。尼莫可能同一高分子的一部分体重复杂。TNF、坦克、TNF receptor-associated因素(TRAF) 2,在诱导NF-kappaB TRAF6活动。NF-kappaB通路。

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