...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >Linkage between EGFR family receptors and nuclear factor kappaB (NF-kappaB) signaling in breast cancer.
【24h】

Linkage between EGFR family receptors and nuclear factor kappaB (NF-kappaB) signaling in breast cancer.

机译：表皮生长因子受体家族之间的联系和核受体因素kappaB (NF-kappaB)信号在乳房癌症。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the United States there are 225,000 new cases of invasive breast cancer annually, and at least 50,000 women are diagnosed with ductal carcinoma in situ (DCIS). Breast cancer is a collection of disorders of mammary epithelial cells with distinct pathological characteristics and diverse clinical manifestations. Breast cancers are divided broadly into four classes by the level of the biomarkers HER2 (erbB2/neu) and the estrogen receptor (ER). Histologic grade is also an important modifier of breast cancer taxonomy and behavior. Broadly speaking, breast cancer can be divided into those that are HER2-positive, containing cancers that are both ER-positive and negative, cancers that are ER-positive and divided into high-grade and low-grade tumors, and the remaining but important class of cancers that are both ER-negative and HER2-negative. These last cancers are called basal-like and were first recognized as a distinct group by gene expression arrays. Nuclear factor kappaB (NF-kappaB) is family of multifunctional transcription factors that when activated generate pleotrophic changes in target cells. Elevated levels of active NF-kappaB are detected in many human diseases including breast cancers. High-level active NF-kappaB is detected in specific subclasses of breast cancers briefly described above, predominantly in ER-negative and epidermal growth factor family receptor (EGFR) overexpressing breast cancers (predominantly HER2 amplified cancers). This article is focused on the role of NF-kappaB activation initiated by the EGFR family receptors in subclasses of breast cancer. The combined influence of EGFR family receptors and NF-kappaB signaling on the transformation of ER-negative human mammary epithelial cell is illustrated.
机译：在美国有225000新病例每年的乳腺浸润性癌,至少50000名妇女被诊断为导管癌原位(DCIS)。障碍的乳腺上皮细胞不同的病理特点和多样化临床表现。大致分为四类的水平生物标志物的HER2 (erbB2 / neu)和雌激素受体(ER)。重要的乳腺癌分类和修饰符的行为。分为那些her2阳性,含有雌激素受体阳性和癌症负的,雌激素受体阳性和癌症分为高级和低级的肿瘤剩下的但重要的类的癌症都是雌激素阴性her2阴性。去年癌症称为官腔,第一公认为一组基因表达数组。家庭多功能的转录因子当激活生成pleotrophic变化在目标细胞。在许多人类疾病NF-kappaB检测包括乳腺癌。在具体的子类NF-kappaB检测乳腺癌短暂上面所描述的那样,主要在er阴性和表皮生长因子受体(EGFR) overexpressing家庭乳腺癌(主要是HER2放大癌症)。NF-kappaB激活由表皮生长因子受体家族受体在乳腺癌的子类。表皮生长因子受体家族的受体和组合的影响NF-kappaB信号的变换人类乳腺上皮细胞er阴性画报。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号