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首页> 外文期刊>Journal of Cellular Physiology >Erythroid cell differentiation is characterized by nuclear matrix localization and phosphorylation of protein kinases C (PKC) alpha, delta, and zeta.
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Erythroid cell differentiation is characterized by nuclear matrix localization and phosphorylation of protein kinases C (PKC) alpha, delta, and zeta.

机译：红色的细胞分化的特点是核基质本地化和磷酸化蛋白激酶C (PKC)α,三角洲,ζ。

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摘要

Protein kinases C (PKC) zeta expression and phosphorylation at nuclear level during dimethyl sulfoxide (DMSO)-induced differentiation in Friend erythroleukemia cells have been previously reported, suggesting a possible role of this PKC isoform in the DMSO-related signaling. In order to shed more light on this tantalizing topic, we investigated PKC intracellular and sub-cellular localization and activity during DMSO-induced erythroid differentiation. Results indicated that at least PKC alpha, zeta, and delta are strongly and temporally involved in the DMSO-induced differentiation signals since their expression and phosphorylation, though at different extents, were observed during treatments. Intriguingly, while PKC alpha and zeta associate to the nuclear matrix during the differentiation event, PKC delta appears to be residentially associated to the nuclear matrix. Furthermore, an evident downregulation of the beta-globin gene transcription (differentiation hallmark) was detected upon a progressive inhibition of these PKC isoforms by means of specific inhibitors, indicating, therefore, that PKC alpha, zeta, and delta phosphorylation play a crucial role in the control of erythroid differentiation.
机译：蛋白激酶C (PKC)和zeta表达式磷酸化在核级二甲亚砜(DMSO)全身的分化之前朋友红白血病细胞报道,表明这种PKC的可能角色同种型DMSO-related信号。为了更清楚地了解这个诱人的话题,我们研究PKC细胞和亚细胞在DMSO-induced本地化和活动红细胞分化。至少PKCα,ζ,δ强烈和参与DMSO-induced暂时因为他们的表达分化信号和磷酸化,尽管在不同的区段,治疗期间观察。而PKCα和ζ副核矩阵在分化事件,PKCδ似乎在居住方面相关核矩阵。downregulationβ球蛋白基因转录(分化标志)发现在一个进步的抑制PKC通过特定的抑制剂,因此表明,PKCα,ζ,三角洲磷酸化发挥着至关重要的作用红细胞分化的控制。

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