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首页> 外文期刊>Journal of Cellular Physiology >Myocilin is associated with mitochondria in human trabecular meshwork cells.
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Myocilin is associated with mitochondria in human trabecular meshwork cells.

机译：在人类Myocilin与线粒体有关小梁网细胞。

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摘要

The trabecular meshwork (TM) is a specialized tissue located at the chamber angle of the eye next to the cornea. This tissue is believed to be responsible for regulation of the aqueous humor outflow and control of the intraocular pressure (IOP). Alterations in functions of the TM may lead to IOP elevation and development of glaucoma, a major cause of blindness. The myocilin gene has recently been directly linked to open-angle glaucomas. The gene product was originally identified as a protein inducible in TM cells by treatment with glucocorticoids such as dexamethasone (DEX) and termed TIGR (TM inducible-glucocorticoid response). The exact nature and function of the myocilin protein so far still remain elusive. In this study, myocilin was localized to the perinuclear region of both DEX-treated and control TM cells. Its distribution overlapped considerably with that of mitochondria. Subcellular fractionation and Western blot analyses suggested a rather extensive association of myocilin with mitochondria. The DEX-treated TM cells were found to undergo apoptosis, when exposed to anti-Fas antibody, to a significantly higher degree than the untreated control cells. It appears that the TM cell integrity remains intact after DEX treatment. However, the induced myocilin or myocilin-mitochondria association seems to render the cells more susceptible to a second stress or challenge. This vulnerability may be the basis that ultimately leads to pathological consequences.
机译：小梁网(TM)是一个专业组织位于眼睛的室角旁边的角膜。房水的负责监管流出和控制眼压(IOP)。导致眼压高程和发展青光眼,失明的主要原因。myocilin最近直接相关的基因为开角青光眼。最初被确定为一种蛋白质诱导小梁网细胞通过糖皮质激素治疗地塞米松(DEX),称为TIGR (TMinducible-glucocorticoid响应)。myocilin蛋白质的性质和功能目前仍然难以捉摸。是本地化的细胞核周围的地区DEX-treated和控制小梁网细胞。分布重叠的线粒体。免疫印迹分析建议广泛myocilin协会线粒体。进行细胞凋亡,当暴露于anti-Fas度显著高于抗体未经处理的控制细胞。小梁网细胞完整性敏捷后仍然完好无损治疗。myocilin-mitochondria协会似乎呈现细胞更容易受到压力或挑战。最终导致病态的后果。

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