Branched-chain amino acids: a role in skeletal muscle proteolysis in catabolic states?

Busquets S; Alvarez B; Lopez Soriano FJArgiles JM

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Branched-chain amino acids: a role in skeletal muscle proteolysis in catabolic states?

机译：支链氨基酸:骨骼的作用肌肉蛋白水解作用在异化的状态吗?

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A 48-h starvation period resulted in a great increase in muscle proteolysis-as measured following the release of tyrosine into the medium-in incubated isolated rat extensor digitorum longus (EDL) muscles. We have quantified the contribution of the different proteolytic systems to the increased protein degradation and observed a considerable activation in the ATP-dependent proteolytic (60%) and in the calcium-dependent (125%) systems, while no increases were observed in lysosomal proteolysis. The addition of 10 mM leucine to the incubation medium did not result in any changes in either total proteolytic rate or the activity rates of any of the different systems studied. In addition, the presence of the amino acid did not influence the levels of mRNA for the different genes studied-ubiquitin, C8 proteasome subunit, E2 conjugating enzyme, m-calpain, and cathepsin B. In a similar way, as observed during starvation, tumor growth resulted in increased protein degradation in incubated isolated EDL muscles from animals bearing the Yoshida AH-130 ascites hepatoma. The increased rate of protein degradation affected all the proteolytic systems studied: ATP- and calcium-dependent and lysosomal. Finally, leucine addition (10 mM), although not able to revert the increased proteolytic rate, resulted in a decrease in the gene expression for ubiquitin, C8 proteasome subunit and cathepsin B.

机译：一个48小时饥饿导致了一个伟大的时期增加肌肉proteolysis-as测量后释放的酪氨酸中孵化孤立的老鼠伸肌digitorum长(EDL)肌肉。量化的贡献不同蛋白水解系统增加蛋白质退化和看到一个相当大的在ATP-dependent激活蛋白水解(60%)和calcium-dependent(125%)系统,虽然没有增加观察溶酶体蛋白质水解。孵化中并没有导致任何改变在总蛋白水解率或活动利率的不同的系统研究。此外,氨基酸的存在没有影响的mRNA水平不同基因studied-ubiquitin C8蛋白酶体亚基,E2接合酶、m-calpain和组织蛋白酶以类似的方式,期间观察到的饥饿、肿瘤生长导致增加蛋白质降解孵化孤立的联盟从动物肌肉吉田ah - 130腹水肝癌。退化影响所有的蛋白水解系统研究:ATP - calcium-dependent和溶酶体。虽然不能恢复增加蛋白水解率,导致下降泛素基因表达,C8蛋白酶体子单元和组织蛋白酶B。

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来源
《Journal of Cellular Physiology》 |2002年第3期|283-289|共7页
作者
Busquets S; Alvarez B; Lopez Soriano FJArgiles JM;
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作者单位

Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.;

icknowl.com.au;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Proteolysis; Cathepsin B; protein degradationAmino Acids;

机译：酸;

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Branched-chain amino acids: a role in skeletal muscle proteolysis in catabolic states?

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