Gap junctions, homeostasis, and injury.

De Maio A; Vega VL; Contreras JE

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Gap junctions, homeostasis, and injury.

机译：缝隙连接、内稳态和伤害。

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Gap junctions (Gj) play an important role in the communication between cells of many tissues. They are composed of channels that permit the passage of ions and low molecular weight metabolites between adjacent cells, without exposure to the extracellular environment. These pathways are formed by the interaction between two hemichannels on the surface of opposing cells. These hemichannels are formed by the association of six identical subunits, named connexins (Cx), which are integral membrane proteins. Cell coupling via Gj is dependent on the specific pattern of Cx gene expression. This pattern of gene expression is altered during several pathological conditions resulting in changes of cell coupling. The regulation of Cx gene expression is affected at different levels from transcription to post translational processes during injury. In addition, Gj cellular communication is regulated by gating mechanisms. The alteration of Gj communication during injury could be rationalized by two opposite theories. One hypothesis proposes that the alteration of Gj communication attenuates the spread of toxic metabolites from the injured area to healthy organ regions. The alternative proposition is that a reduction of cellular communication reduces the loss of important cellular metabolisms, such as ATP and glucose.

机译：缝隙连接(Gj)中扮演重要角色细胞的许多组织之间的沟通。是由渠道,允许通过吗离子和低分子量代谢物相邻细胞之间,没有接触细胞外环境。由两个之间的互动hemichannels反对表面的细胞。这些hemichannels由协会六个相同的子单元,连接素(Cx)命名,这是完整的膜蛋白。通过Gj依赖于特定的耦合Cx基因表达的模式。在几个基因表达改变病理条件导致的变化细胞耦合。在不同水平表达的影响转录后转化过程在受伤。沟通是由闸门机制。受伤期间Gj沟通的改变可以通过两种截然相反的合理化理论。提出了一种假设,即Gj的变更交流变弱毒的传播代谢物受伤部位的健康器官区域。减少细胞的沟通减少损失的重要的细胞新陈代谢,如ATP和葡萄糖。

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来源
《Journal of Cellular Physiology》 |2002年第3期|269-282|共14页
作者
De Maio A; Vega VL; Contreras JE;
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作者单位

icknowl.com.au;

Division of Pediatric Surgery and Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. ademaio;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
FORMATION DAMAGE; modality-specific; cytologyLOW MOLECULAR WEIGHTInjuriesCommunication ResearchCellular communicationsGap Junctions;

机译：地层损害;modality-specific cytologyLOW分子WEIGHTInjuriesCommunicationResearchCellular communicationsGap连接;

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Gap junctions, homeostasis, and injury.

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