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首页> 外文期刊>Journal of Cellular Physiology >CD44v10 expression in the mouse and functional activity in delayed type hypersensitivity.
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CD44v10 expression in the mouse and functional activity in delayed type hypersensitivity.

机译：CD44v10表达鼠标和功能活动推迟类型超敏反应。

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摘要

We have described recently that expression of CD44 exon v10 (CD44v10) is down-regulated upon metastasis of squamous cell carcinoma, whereas it is up-regulated in skin metastases of malignant melanoma. The striking regulation of CD44v10 prompted us to generate a murine CD44v10-specific monoclonal antibody to define expression and possible functions of this particular CD44 variant isoform. In the mouse, expression of exon v10 was restricted to basal layers of the epidermis and squamous epithelium of the oral cavity, the esophagus, the omasum, glandular epithelium of the submandibular and the uterine gland, as well as subpopulations of bone marrow cells and activated lymphocytes. Expression started late during development, e.g., was not observed before day 16 of gestation and there was no evidence for developmental regulation of CD44v10 expression. Functional in vivo studies revealed that anti-CD44v10 had no effect on wound healing but inhibited edema and granuloma formation in delayed type hypersensitivity (DTH). Furthermore, lymphocyte-monocyte interactions could be inhibited by anti-CD44v10. Because a CD44v10 transfected tumour line did not show any distinct pattern of cell-matrix or cell-cell adhesion, the data point toward an involvement of CD44v10 in cell migration, possibly by acting as a target structure for cytokines/chemokines provided by the contacted partner cell.
机译：我们已经描述了最近CD44的表达外显子v10 (CD44v10)衰减鳞状细胞癌的转移,而它上调的皮肤转移恶性吗黑素瘤。促使我们生成一个小鼠CD44v10-specific单克隆抗体来定义和表达式可能这个CD44的函数同种型变体。v10是局限于基底的层表皮和口腔鳞状上皮食管腔,重瓣胃腺颌下上皮细胞和子宫腺,以及亚种群的骨髓细胞和淋巴细胞激活。在开发过程中起步较晚,例如,没有16天前观察妊娠有没有证据表明发展的监管CD44v10表达式。透露,anti-CD44v10没有影响伤口治疗但抑制水肿和肉芽肿形成延迟型超敏反应(DTH)。此外,lymphocyte-monocyte交互可以通过anti-CD44v10抑制。没有任何CD44v10转染肿瘤行不同的模式cell-matrix或信息附着力,数据指向的参与CD44v10在细胞迁移,可能通过扮演细胞因子/趋化因子的目标结构联系合作伙伴提供的细胞。

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