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首页> 外文期刊>Journal of Cellular Physiology >Interleukin-10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast-like cells in rat bone marrow culture system.
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Interleukin-10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast-like cells in rat bone marrow culture system.

机译：白细胞介素- 10”选择性地抑制osteoclastogenesis通过抑制分化破骨细胞的祖细胞进入preosteoclast-like鼠骨髓细胞培养系统。

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摘要

Recombinant human interleukin-10 (hIL-10) inhibited the formation of osteoclast-like multinucleated cells in rat whole bone marrow cultures. The effect of hIL-10 on the process of osteoclast formation was further examined, since the process of osteoclast formation includes the proliferation and the differentiation of osteoclast progenitors into mononuclear preosteoclasts and the fusion of preosteoclasts into multinucleated osteoclasts. In the nonadherent bone marrow cell culture system, which was free of stromal cells and formed preosteoclast-like cells, hIL-10 significantly inhibited the formation of preosteoclast-like cells even at a very low concentration (0.5 U/ml). The strong inhibition appeared even after treatment with hIL-10 for only the first 24 h of the culture. However, hIL-10 did not affect the fusion process of preosteoclast-like cells to form osteoclast-like multinucleated cells in the rat coculture system of preosteoclast-like cells with primary osteoblasts. Furthermore, hIL-10 completely inhibited the colony formation induced by granulocyte macrophage colony-stimulating factor (GM-CSF). These findings suggest that the inhibition of osteoclastogenesis by hIL-10 started at the early stage of the differentiation of osteoclast progenitors to preosteoclasts.
机译：重组人白细胞介素- 10”(hIL-10)抑制osteoclast-like的形成多核细胞在大鼠骨髓文化。破骨细胞形成进一步检查,破骨细胞的形成包括的过程增殖和分化破骨细胞祖细胞进入单核preosteoclasts preosteoclasts的融合在多核破骨细胞。不依从骨髓细胞培养系统,那是免费的基质细胞和形成preosteoclast-like细胞,hIL-10显著抑制preosteoclast-like的形成细胞即使在很低浓度(0.5U /毫升)。hIL-10治疗的第一个24小时的文化。融合preosteoclast-like细胞的过程形成osteoclast-like多核细胞老鼠coculture preosteoclast-like细胞体系与主要的成骨细胞。完全抑制集落形成诱导由粒细胞巨噬细胞集落刺激因子(gm - csf)。抑制osteoclastogenesis hIL-10开始的早期分化preosteoclasts破骨细胞的祖细胞。

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