Sculpting Metal-binding Environments in De Novo Designed Three-helix Bundles

Plegaria Jefferson S.; Pecoraro Vincent L.

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Sculpting Metal-binding Environments in De Novo Designed Three-helix Bundles

机译：雕刻在新创Metal-binding环境设计Three-helix包

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De novo protein design is a biologically relevant approach used to study the active centers of native metalloproteins. In this review, we will first discuss the design process in achieving alpha D-3, a de novo designed three-helix bundle peptide with a well-defined fold. We will then cover our recent work in functionalizing the alpha D-3 framework by incorporating a tris(cysteine) and tris(histidine) motif. Our first design contains the thiol-rich sites found in metalloregulatory proteins that control the levels of toxic metal ions (Hg, Cd, and Pb). The latter design recapitulates the catalytic site and activity of a natural metalloenzyme carbonic anhydrase. The review will conclude with future design goals aimed at introducing an asymmetric metal-binding site in the alpha D-3 framework.

机译：从头设计是一个生物学上相关的蛋白质方法用于研究的活性中心原生金属离子。首先讨论实现的设计过程αd 3,从头设计three-helix包肽具有定义良好的褶皱。我们最近的构建工作αd 3框架,通过融合一个三羟甲基氨基甲烷(半胱氨酸)和三羟甲基氨基甲烷(组氨酸)液液主题。第一个设计包含thiol-rich网站找到在metalloregulatory蛋白质控制水平的有毒金属离子(Hg、Cd和Pb)。后者设计概括催化部位和活动的自然金属酶碳酸脱水酶。设计目标旨在引入非对称metal-binding网站αd 3框架。

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《Israel journal of chemistry》 |2015年第1期|85-95|共11页
作者
Plegaria Jefferson S.; Pecoraro Vincent L.;
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Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA;

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正文语种英语
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design target; Sculpture; Adrenergic alpha-AntagonistsMetalloproteinsdesign processACTIVE CENTREmetal ionsActive Site;

机译：设计目标;雕塑;肾上腺素alpha-AntagonistsMetalloproteinsdesignprocessACTIVE CENTREmetal ionsActive网站;

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Sculpting Metal-binding Environments in De Novo Designed Three-helix Bundles

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