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首页> 外文期刊>Israel journal of chemistry >P450(BM3)-Axial Mutations: A Gateway to Non-Natural Reactivity
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P450(BM3)-Axial Mutations: A Gateway to Non-Natural Reactivity

机译：P450 (BM3)轴向变异:网关非天然的反应性

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Enzymes capable of catalyzing non-natural reactions have the potential to alter the way relevant molecules are prepared on-scale. Efforts to this end have largely focused on combining non-natural cofactors with proteins lacking catalytic function to obtain non-natural reactivity. An alternative approach is to utilize a native cofactor to catalyze non-natural reactions. Recently, our group demonstrated that heme-containing cytochrome P450s are able to catalyze the highly selective cyclopropanation of alkenes. Superior activity was observed upon changing the axial cysteine to serine ("P411"). Mutation at the conserved axial ligand has enabled P450s to catalyze other non-natural reactions such as N-H insertion and C-H amination.
机译：酶能催化非天然的反应有可能改变的方式相关的分子准备以规模。为此也主要集中在结合非天然的代数余子式和蛋白质缺乏催化功能获得非天然的反应性。本机代数余子式催化非天然的反应。heme-containing细胞色素p450酶类能够催化高度选择性的摘要烯烃。改变轴向半胱氨酸丝氨酸(“P411”)。突变的守恒的轴向配位体启用p450酶类催化非天然的反应- h插入和碳氢键等氨基化。

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