Quantification of the radio-metabolites of the serotonin-1A receptor radioligand [carbonyl- 11C]WAY-100635 in human plasma: An HPLC-assay which enables measurement of two patients in parallel

NicsL.; HahnA.; ZeilingerM.; VrakaC.; UngersboeckJ.; HaeuslerD.; HartmannS.; WagnerK.-H.; LanzenbergerR.; WadsakW.; MitterhauserM.

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Quantification of the radio-metabolites of the serotonin-1A receptor radioligand [carbonyl- 11C]WAY-100635 in human plasma: An HPLC-assay which enables measurement of two patients in parallel

机译：人体血浆中5-羟色胺-1A受体放射性配体[羰基-11C] WAY-100635的放射性代谢产物的定量：HPLC测定法，可以并行测量两名患者

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[Carbonyl- 11C]WAY-100635 is a potent and effective antagonist for the 5-HT 1A receptor subtype. We aimed to assess the status of [carbonyl- 11C]WAY-100635 and its main radio-metabolites, [carbonyl- 11C]desmethyl-WAY-100635 and [carbonyl- 11C]cyclohexanecarboxylic acid, on the basis of an improved radio-HPLC method. Common methods were characterized by preparative HPLC columns with long runtimes and/or high flow rates. Considering the short half-life of C-11, we developed a more rapid and solvent saving HPLC assay, allowing a fast, efficient and reliable quantification of these major metabolites.

机译：[Carbonyl-11C] WAY-100635是5-HT 1A受体亚型的有效有效拮抗剂。我们基于改进的放射线HPLC，评估[羰基11C] WAY-100635及其主要放射性代谢物[羰基11C] desmethyl-WAY-100635和[羰基11C]环己烷羧酸的状态方法。常用方法的特点是制备型HPLC色谱柱具有较长的运行时间和/或高流速。考虑到C-11的半衰期短，我们开发了一种更快，更省溶剂的HPLC分析方法，可以对这些主要代谢物进行快速，高效和可靠的定量。

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |2012年第12期|共7页
作者
NicsL.; HahnA.; ZeilingerM.; VrakaC.; UngersboeckJ.; HaeuslerD.; HartmannS.; WagnerK.-H.; LanzenbergerR.; WadsakW.; MitterhauserM.;
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正文语种 eng
中图分类原子核物理学、高能物理学;
关键词
5-HT; Carbon-11; Metabolites; PET; Serotonin-1A; WAY100635;

机译：5-HT;碳11;代谢产物;PET;血清素1A;WAY100635;

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外文文献

1. Quantification of the radio-metabolites of the serotonin-1A receptor radioligand [carbonyl- 11C]WAY-100635 in human plasma: An HPLC-assay which enables measurement of two patients in parallel [J] . NicsL., HahnA., ZeilingerM., Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2012,第12期

机译：人体血浆中5-羟色胺-1A受体放射性配体[羰基-11C] WAY-100635的放射性代谢产物的定量：HPLC测定法，可以并行测量两名患者
2. The PET radioligand (carbonyl-(11)C)desmethyl-WAY-100635 binds to 5-HT(1A) receptors and provides a higher radioactive signal than (carbonyl-(11)C)WAY-100635 in the human brain. [J] . Andree Bengt, Halldin Christer, Pike VictorW, The Journal of Nuclear Medicine . 2002,第3期

机译：PET放射性配体（羰基-（11）C）去甲基WAY-100635与5-HT（1A）受体结合，在人脑中比（羰基-（11）C）WAY-100635提供更高的放射性信号。
3. Two C-Methyl Derivatives of [11C]WAY-100635 – Effects of an Amido α-Methyl Group on Metabolism and Brain 5-HT1A Receptor Radioligand Behavior in Monkey* [J] . Julie A. McCarron PhD, Sandrine Marchais-Oberwinkler PhD, Victor W. Pike PhD, Molecular Imaging and Biology . 2005,第3期

机译：[11 C] WAY-100635的两种C-甲基衍生物–酰胺基α-甲基对猴子的代谢和大脑5-HT1A 受体放射性配体行为的影响*
4. Quantification assay of imatinib in patient plasma and characterization of its metabolism in human urine and liver microsomes using LC-ESI-MS/MS [C] . A Deroussent, A Paci, C Delbaldo, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：使用LC-ESI-MS / MS的患者血浆患者血浆中伊马替尼对其代谢的表征及其尿液中的表征
5. Human Biodistribution and Dosimetry of 11C-CUMI-101 an Agonist Radioligand for Serotonin-1A Receptors in Brain [O] . Christina S. Hines, Jeih-San Liow, Paolo Zanotti-Fregonara, 2011

机译：的人的生物分布和剂量测定11C-粗米-101激动剂放射性配体对血清素1a受体在脑
6. First-in-Human Evaluation of 18F-Mefway, a PET Radioligand Specific to Serotonin-1A Receptors [O] . Ansel T. Hillmer, Dustin W. Wooten, Alisha K. Bajwa, 2014

机译：18F-Mefway的首先评价，一种特异于血清素-1a受体的宠物放射性配体

Quantification of the radio-metabolites of the serotonin-1A receptor radioligand [carbonyl- 11C]WAY-100635 in human plasma: An HPLC-assay which enables measurement of two patients in parallel

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