Biodistribution and metabolism of 11C-labeled Kendine 91 in mice and rats

Gómez-VallejoV.; MartínA.; AginagaldeM.; SanSebastianE.; PadroD.; CossíoF.P.; LlopJ.

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Biodistribution and metabolism of 11C-labeled Kendine 91 in mice and rats

机译：11C标记的Kendine 91在小鼠和大鼠中的生物分布和代谢

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The biodistribution pattern of [ 11C]Kendine 91 (a novel HDAC inhibitor) after IV administration has been evaluated using Positron Emission Tomography (rats) and gamma counting of dissected tissues (rats and mice) at different doses (1μg/kg and 10.0mg/kg). Metabolism in mice plasma has been also investigated by radio-HPLC. Obtained results (fast accumulation in lungs, heart, kidneys and liver; lower uptake in pancreas and muscle) are in concordance with previously reported results using HPLC/MS-MS. Plasma analysis studies showed a fast metabolism of the radiotracer.

机译：已经使用正电子发射断层扫描（大鼠）和不同剂量（1μg/ kg和10.0mg / kg）的解剖组织（大鼠和小鼠）的γ计数，评估了静脉给药后[11C] Kendine 91（一种新型的HDAC抑制剂）的生物分布模式。公斤）。还已经通过放射-HPLC研究了小鼠血浆中的代谢。获得的结果（在肺，心脏，肾脏和肝脏中快速积累;在胰腺和肌肉中的摄取降低）与先前报道的使用HPLC / MS-MS的结果一致。血浆分析研究表明放射性示踪剂快速代谢。

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |2012年第10期|共7页
作者
Gómez-VallejoV.; MartínA.; AginagaldeM.; SanSebastianE.; PadroD.; CossíoF.P.; LlopJ.;
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正文语种 eng
中图分类原子核物理学、高能物理学;
关键词
Biodistribution; Carbon-11; HDAC inhibitor; Kendine 91; MRI; PET;

机译：生物分布;碳11;HDAC抑制剂;Kendine 91;MRI;PET;

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1. Biodistribution and metabolism of 11C-labeled Kendine 91 in mice and rats [J] . Gómez-VallejoV., MartínA., AginagaldeM., Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2012,第10期

机译：11C标记的Kendine 91在小鼠和大鼠中的生物分布和代谢
2. Pharmacokinetics and tissue distribution of Kendine 91, a novel histone deacetylase inhibitor, in mice. [J] . Otaegui D, Rodriguez Gascon A, Zubia A, Cancer chemotherapy and pharmacology. . 2009,第1期

机译：新型组蛋白脱乙酰基酶抑制剂Kendine 91在小鼠中的药代动力学和组织分布。
3. Pharmacokinetics and tissue distribution of Kendine 91, a novel histone deacetylase inhibitor, in mice [J] . Dorleta Otaegui, Alicia Rodríguez-Gascón, Aizpea Zubia, Cancer Chemotherapy and Pharmacology . 2009,第1期

机译：新型组蛋白脱乙酰基酶抑制剂Kendine 91在小鼠体内的药代动力学和组织分布
4. Comparative Biodistribution of PAMAM Dendrimers and HPMA Copolymers in Ovarian Tumor-Bearing Mice [C] . S. Sadekar, A. Ray, M. Janat-Amsbury, Annual meeting exposition of the Controlled Release Society . 2011

机译：PAMAM树状大分子和HPMA共聚物在卵巢肿瘤小鼠中的比较生物分布
5. Lactational changes in bone metabolism in mice lacking parathyroid hormone (PTH). [D] . Buckle, Kerri Lorraine. 2006

机译：缺乏甲状旁腺激素（PTH）的小鼠骨骼代谢的乳酸变化。
6. LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice [O] . Cong Thuc Le, Giang Nguyen, So Young Park, 2012

机译：LY2405319是成纤维细胞生长因子21的类似物，可通过抑制小鼠体内的琥珀酸-G蛋白偶联受体91（GPR91）途径改善α-平滑肌肌动蛋白的产生
7. Synthesis of 11C-labeled imipramine and its biodistribution in mice: A potential tracer for positron emission tomography. [O] . Hitoshi NAKAMURA, Kiyoto EDO, Takanori HISHINUMA, 1989

机译：在小鼠中合成11C标记的含染色脒及其生物分布：正电子发射断层扫描的潜在示踪剂。
8. TISCON, A BASIC Computer Program for the Calculation of the Biodistribution of Radionuclide-Labelled Drugs in Rats and Mice [R] . Maddalena, D. J. 1983

机译：TIsCON，一种计算大鼠和小鼠放射性核素标记药物生物分布的基本计算机程序

Biodistribution and metabolism of 11C-labeled Kendine 91 in mice and rats

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