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首页> 外文期刊>Shock: Molecular, cellular, and systemic pathobiological aspects and therapeutic approaches = The official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies >Hypertonic saline and pentoxifylline prevent lung injury and bacterial translocation after hemorrhagic shock.
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Hypertonic saline and pentoxifylline prevent lung injury and bacterial translocation after hemorrhagic shock.

机译：高渗盐水和pentoxifylline防止肺受伤后肠道细菌易位和出血性休克。

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摘要

Previous reports have shown beneficial effects of pentoxifylline (PTX) and hypertonic saline (HS) in the treatment of hemorrhagic shock. We compared the effects of these solutions to those of conventional lactated Ringer's (LR) treatment on bacterial translocation (BT), lung injury and total and differential cell count in the bronchoalveolar lavage fluid (BAL) after hemorrhagic shock. Rats (280-330 g) were bled to a MAP of 35 mmHg for 1 h and then randomized into 4 groups: LR (3x shed blood); HS (7,5% NaCl, 4 mL/kg); LR+PTX (25 mg/kg) and SHAM (no shock, no treatment). Additionally, total shed blood was reinfused. At 24 h lung injury was analyzed by a pathologist blinded to the groups, and a score was calculated. BT was determined by microbiological cultures of mesenteric lymph node complex. BAL was performed on a separate set of animals that received the same treatments. Lung score was significantly higher in LR group (11.5+/-1.4) as compared to HS (6.8+/-0.9), and PTX treated animals (7.2+/-0.9). The percentage of neutrophils in the BAL of LR animals (15.8%) was also significantly higher as compared with HS (5.25%) and PTX groups (9.72%). BT was noted in 50% of rats for LR group, 30% for PTX, 10% for HS and 0% for sham group. HS and PTX reduced BT and lung injury after hemorrhage. Attenuation of lung injury could be the result of less neutrophil infiltration into the lungs of HS and PTX treated animals. LR resuscitation caused pronounced lung injury and BT.
机译：先前的报道表明有益的影响pentoxifylline (PTX)和高渗盐水(HS)在出血性休克的治疗。而这些解决方案的影响传统的乳酸林格液(LR)的治疗细菌易位(BT),肺损伤和微分细胞总数支气管肺泡灌洗液(BAL)之后出血性休克。35毫米汞柱的地图1 h,然后随机分为4组:LR (3 x流血);毫升/公斤);治疗)。被重新。病理学家失明组,和一个分数计算了。微生物肠系膜淋巴结的文化复杂。动物接受同样的治疗。得分明显高于LR组(11.5 + / - -1.4)相比HS(6.8 + / - -0.9),和PTX治疗动物(7.2 + / - -0.9)。中性粒细胞的BAL LR动物(15.8%)也显著高与HS相比呢(5.25%)和PTX组(9.72%)。PTX为LR组大鼠的50%,30%,10%的商品为虚假的组和0%。肺损伤后出血。损伤可能是由于中性粒细胞减少渗透到肺部的HS和PTX治疗动物。受伤和BT。

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