Synthesis of optically active dodecaborate-containing L-amino acids for BNCT.

Kusaka S; Hattori Y; Uehara K; Asano T; Tanimori S; Kirihata M

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Synthesis of optically active dodecaborate-containing L-amino acids for BNCT.

机译：用于BNCT的含旋光性十二酸酯的L-氨基酸的合成。

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A convenient and simple synthetic method of dodecaboratethio-L-amino acid, a new class of tumor-seeking boron carrier for BNCT, was accomplished from S-cyanoethylthioundecahydro-closo-dodecaborate (S-cyanoethyl-(10)BSH, [(10)B(12)H(11)](2-)SCH(2)CH(2)CN) and bromo-L-alpha-amino acids by nearly one step S-alkylation. An improved synthesis of S-cyanoethyl-(10)BSH, a key starting compound for S-alkylation, was also performed by Michael addition of (10)BSH with acryronitrile in high yield. Four kinds of new dodecaboratethio-L-amino acids were obtained in optically pure form without the need for any optical resolution.

机译：从S-氰基乙基硫代十一碳二氢-十二烷酸酯（S-氰基乙基-（10）BSH，[（10） B（12）H（11）]（2-）SCH（2）CH（2）CN）和溴-L-α-氨基酸通过近一个步骤的S-烷基化。 S-氰基乙基-（10）BSH（一种用于S-烷基化的关键起始化合物）的改进合成方法也可以通过高产率地将（10）BSH与丙烯腈进行迈克尔加成反应来进行。以光学纯的形式获得了四种新的十二硼酸硫代-L-氨基酸，而无需任何光学拆分。

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |2011年第12期|共3页
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Kusaka S; Hattori Y; Uehara K; Asano T; Tanimori S; Kirihata M;
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中图分类原子核物理学、高能物理学;
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1. Synthesis of optically active dodecaborate-containing L-amino acids for BNCT. [J] . Kusaka S, Hattori Y, Uehara K, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2011,第12期

机译：用于BNCT的含旋光性十二酸酯的L-氨基酸的合成。
2. Ionic liquid catalyzed synthesis and characterization of heterocyclic and optically active poly (amide-imide)s incorporating l-amino acids [J] . Saeed Zahmatkesh Amino Acids . 2011,第2期

机译：离子液体催化合成和表征掺有l-氨基酸的杂环和光学活性聚（酰胺-酰亚胺）
3. Microwave-assisted synthesis and characterization of heterocyclic, and optically active poly(amide-imide)s incorporating L-amino acids [J] . Abdol R. Hajipour, Saeed Zahmatkesh, Arnold E. Ruoho Polymers for advanced technologies . 2008,第12期

机译：微波辅助合成和表征掺有L-氨基酸的杂环和旋光聚（酰胺-酰亚胺）
4. Discovery of novel L-amino acid α-ligases and application to dipeptide synthesis^ [C] . Toshinobu Arai, Yuji Nakazawa, Atsushi Noguchi International Peptide Symposium . 2009

机译：发现新型L-氨基酸α-连接酶及其在二肽合成的应用^
5. Synthesis of symmetrical and optically active alpha-amino acids via homologation of nickel(II) complexed glycine Schiff bases. [D] . Ellis, Trevor K. 2007

机译：通过镍（II）配合的甘氨酸席夫碱的同系物合成对称和旋光的α-氨基酸。
6. Synthesis of optically active amino acids from alpha-keto acids with Escherichia coli cells expressing heterologous genes. [O] . A Galkin, L Kulakova, T Yoshimura, 1997

机译：由α-酮酸与表达异源基因的大肠杆菌细胞合成旋光氨基酸。
7. Synthesis, Characterization, and Solution Behavior of Optically Active cis b Organocobalt Salen Complexes with l-Amino Acids [O] . -1

机译：用L-氨基酸的光学活性CISB有机钴盐复合物的合成，表征和溶液行为

Synthesis of optically active dodecaborate-containing L-amino acids for BNCT.

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