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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Reusable electrochemical cell for rapid separation of [18F]fluoride from [18O]water for flow-through synthesis of 18F-labeled tracers
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Reusable electrochemical cell for rapid separation of [18F]fluoride from [18O]water for flow-through synthesis of 18F-labeled tracers

机译：可重复使用的电化学电池，用于从[18O]水中快速分离[18F]氟化物，用于18F标记示踪剂的流式合成

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摘要

A brass-platinum electrochemical micro-flow cell was developed to extract [18F]fluoride from an aqueous solution and release it into an organic-based solution, suitable for subsequent radio-synthesis, in a fast and reliable manner. This cell does not suffer electrode erosion and is thus reusable while operating faster by enabling increased voltages. By optimizing temperature, trapping and release potentials, flow rates, and electrode materials, an overall [18F]fluoride trapping and release efficiency of 84±5% (n=7) was achieved. X-ray photoelectron spectroscopy (XPS) was used to analyze electrode surfaces of various metal-metal systems and the findings were correlated with the performance of the electrochemical cell. To demonstrate the reactivity of the released [18F]fluoride, the cell was coupled to a flow-through reactor and automated synthesis of [18F]FDG with a repeatable decay-corrected yield of 56±4% (n=4) was completed in 15min. A multi-human dose of 5.92GBq [18F]FDG was also demonstrated.
机译：开发了黄铜-铂电化学微流槽，以快速，可靠的方式从水溶液中提取[18F]氟化物，然后将其释放到有机基溶液中，适用于后续的放射合成。该电池不会遭受电极腐蚀，因此可重复使用，同时可通过增加电压来加快运行速度。通过优化温度，俘获和释放电位，流速和电极材料，可以实现84±5％（n = 7）的总[18F]氟化物俘获和释放效率。 X射线光电子能谱（XPS）用于分析各种金属-金属系统的电极表面，其发现与电化学电池的性能相关。为了证明释放的[18F]氟化物的反应性，将细胞与流通式反应器偶联，并在可再生的溶液中完成了可重复的56±4％（n = 4）衰变校正产率的[18F] FDG的自动合成。 <15分钟。还证实了多人剂量的5.92GBq [18F] FDG。

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