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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >The preparation of 99mTc-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging
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The preparation of 99mTc-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging

机译：99mTc-DTPA-LSA的制备及其用于肝受体显像的速冻试剂盒

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Diethylenetriaminepentaacetic acid neolactosyl human serum albumin (DTPA-LSA) was prepared and labeled with technetium-99m. The labeling conditions of 99mTc-DTPA-LSA were optimized, and lyophilized kit was developed for instant preparing of 99mTc-DTPA-LSA. 99mTc-DTPA-LSA showed high liver uptake in normal mice (96% ID/g at 5min after injection), and it could be blocked significantly by pre-injecting free neogalactosylalbumin (NGA). Single photon emission computed tomography (SPECT) study was performed in normal Japanese White rabbits and SPECT images with high quality were obtained at 15, 30, 60, and 120min after injection of the radiotracer. The promising biological properties of 99mTc-DTPA-LSA combined with the development of reliable and instant lyophilized DTPA-LSA kit afford the opportunity of hepatic receptor imaging for routine clinical assessment of hepatic function. ? 2012 Elsevier Ltd.
机译：制备二亚乙基三胺五乙酸新乳糖苷人血清白蛋白（DTPA-LSA），并用tech 99m标记。优化了99mTc-DTPA-LSA的标记条件，开发了冻干试剂盒，可即时制备99mTc-DTPA-LSA。 99mTc-DTPA-LSA在正常小鼠中显示出较高的肝脏摄取（注射后5分钟内> 96％ID / g），并且可以通过预先注射游离新半乳糖基白蛋白（NGA）来显着阻断。在普通的日本白兔中进行了单光子发射计算机断层扫描（SPECT）研究，并在注射放射性示踪剂后15、30、60和120分钟获得了高质量的SPECT图像。 99mTc-DTPA-LSA的有前途的生物学特性与可靠且即时冻干的DTPA-LSA试剂盒的开发相结合，为常规的肝功能临床评估提供了肝受体显像的机会。 ？ 2012爱思唯尔有限公司

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