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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Plug-and-play modules for flexible radiosynthesis
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Plug-and-play modules for flexible radiosynthesis

机译：即插即用模块，用于灵活的无线电合成

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摘要

We present a plug-and-play radiosynthesis platform and accompanying computer software based on modular subunits that can easily and flexibly be configured to implement a diverse range of radiosynthesis protocols. Modules were developed that perform: (i) reagent storage and delivery, (ii) evaporations and sealed reactions, and (iii) cartridge-based purifications. The reaction module incorporates a simple robotic mechanism that removes tubing from the vessel and replaces it with a stopper prior to sealed reactions, enabling the system to withstand high pressures and thus provide tremendous flexibility in choice of solvents and temperatures. Any number of modules can rapidly be connected together using only a few fluidic connections to implement a particular synthesis, and the resulting system is controlled in a semi-automated fashion by a single software interface. Radiosyntheses of 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG), 1-[18F]fluoro-4-nitrobenzene ([18F]FNB), and 2'-deoxy-2'-[18F]fluoro-1-β-d-arabinofuranosyl cytosine (d-[18F]FAC) were performed to validate the system and demonstrate its versatility.
机译：我们介绍了一个即插即用的无线电合成平台和随附的基于模块化子单元的计算机软件，可以轻松灵活地对其进行配置，以实现各种各样的无线电合成协议。开发了执行以下功能的模块：（i）试剂存储和输送，（ii）蒸发和密封反应，以及（iii）基于盒的纯化。反应模块采用简单的机械手机制，可在密封反应之前从容器中取出管道并用塞子代替，从而使系统能够承受高压，从而在选择溶剂和温度时提供了极大的灵活性。只需使用少数几个流体连接即可将任意数量的模块快速连接在一起，以实现特定的合成，并且通过单个软件界面以半自动方式控制生成的系统。 2- [18F]氟-2-脱氧-d-葡萄糖（[18F] FDG），1- [18F]氟-4-硝基苯（[18F] FNB）和2'-脱氧-2'-[进行了18F]氟-1-β-呋喃糖基呋喃糖基胞嘧啶（d- [18F] FAC）的验证，并证明了其多功能性。

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