• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Synthesis of radiolabeled protein disulfide isomerase (PDI) inhibitors as new potential PET agents for imaging of the enzyme PDI in neurological disorders and cancer
【24h】

Synthesis of radiolabeled protein disulfide isomerase (PDI) inhibitors as new potential PET agents for imaging of the enzyme PDI in neurological disorders and cancer

机译：放射性标记的蛋白质二硫键异构酶（PDI）抑制剂的合成，作为在神经系统疾病和癌症中对PDI酶成像的新型潜在PET试剂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Carbon-11-labeled substituted ??-tetrahydrocarbolines were prepared from their corresponding phenolic hydroxyl precursors with [11C]CH3OTf through O-[11C]methylation and isolated by simplified SPE in 50-60& decay corrected radiochemical yields at EOB with 185-370GBq/??mol specific activity at EOS. A fluorine-18-labeled substituted ??-tetrahydrocarboline was prepared from its corresponding halo-precursors (X=Cl, Br, I) with K[18F]F/Kryptofix 2.2.2 via the nucleophilic substitution and isolated by HPLC combined with SPE in 25-40& decay corrected radiochemical yield with 37-222GBq/??mol specific activity at EOB. ? 2013 Elsevier Ltd.
机译：用O [[11C]甲基化]由相应的酚羟基前体与[11C] CH3OTf制备碳-11标记的取代的ε-四烃基，并通过简化的SPE在50-60处经衰变校正的放射化学产率为185-370GBq /在EOS处的摩尔比活性。通过亲核取代反应，由其相应的卤素前体（X = Cl，Br，I）经K [18F] F / Kryptofix 2.2.2制备氟-18标记的取代的α-四氢咔啉，并通过HPLC与SPE结合进行分离在25-40℃和衰减校正的放射化学收率下，在EOB处的比活为37-222GBq /Δmol。 ？ 2013爱思唯尔有限公司

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号