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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Development of High-activity Cf Sources for Neutron Brachytherapy
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Development of High-activity Cf Sources for Neutron Brachytherapy

机译：中子近距离放射治疗用高活性Cf源的开发

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The Gershenson Radiation Oncology Center of Wayne State University (WSU), Detroit, Michigan, is using↑(252)Cf medical sources for neutron brachytherapy. These sources are based on a 20-year-old design containing≤30μg↑(252)Cf in the form of a cermet wire of Cf↓(2)O↓(3) in a palladium matrix. The Radiochemical Engineering Development Center (REDC) of Oak Ridge National Laboratory has been asked to develop very compact, high-activity↑(252)Cf neutron sources for use with remote afterloading equipment in order to reduce treatment times and dose to clinical personnel and to expedite treatment of brain and other tumors. To date, the REDC has demonstrated that ↑（252）Cf loadings can be greatly increased in cermet wires and with much smaller diameters. Equipment designed for hot cell fabrication of these wires is being tested. A parallel program is under way to relicense the existing source design for fabrication at the REDe. Published by Elsevier Science Ltd
机译：位于密歇根州底特律的韦恩州立大学（WSU）的Gershenson放射肿瘤学中心正在使用↑（252）Cf医学来源进行中子近距离放射治疗。这些来源基于20年的设计，在钯基体中以Cf↓（2）O↓（3）的金属陶瓷丝的形式包含≤30μg↑（252）Cf。已要求橡树岭国家实验室的放射化学工程开发中心（REDC）开发非常紧凑的高活性↑（252）Cf中子源，以供远程后装设备使用，以减少治疗时间并减少对临床人员和医务人员的剂量。加快脑部和其他肿瘤的治疗。迄今为止，REDC已证明金属陶瓷丝中的↑（252）Cf负载可以大大增加，并且直径要小得多。设计用于这些线的热室制造的设备正在测试中。正在进行并行程序以重新许可现有的源设计以在REDe进行制造。由Elsevier Science Ltd发布

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