A new high-pressure ↑(18)O enriched water target for the production of [↑(18)F]fluoride with 18 MeV protons is described. Recovered yields are 88% of predicted maximum and can be reproduced with an uncertainty of - 4% for beam currents as high as 25 μA and irradiation lengths of up to 90 min. We routinely produce and deliver 37 GBq (1 Ci) of [↑(18)F]fluoride in less than 45 rain irradiation time for synthesis of the radiopharmaceutical [↑(18)F]FDG. Cooling mechanisms and design considerations for high pressure operation of water targets are discussed. A simple and reliable target loading and delivery system is also -presented. # 1997 Elsevier Science Ltd
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