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首页> 外文期刊>Journal of diabetes. >Identification of stress-related microRNA biomarkers in type 2 diabetes mellitus: A systematic review and meta-analysis
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Identification of stress-related microRNA biomarkers in type 2 diabetes mellitus: A systematic review and meta-analysis

机译：识别与压力相关的微生物标志物在2型糖尿病:一个系统回顾和荟萃分析

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Background Many studies have investigated microRNAs (miRNAs) in the detection of type 2 diabetes mellitus (T2DM). Herein, the dysregulated direction of stress-related miRNAs used as biomarkers of T2DM are summarized and analyzed. Methods PubMed, EMBASE, ISI Web of Science, and three Chinese databases were searched for case-control miRNA profiling studies about T2DM. A meta-analysis under a random effect was performed. Subgroup analysis was conducted based on different tissues and species. Sensitivity analysis was conducted to confirm the robustness among studies. The effect size was pooled using ln odds ratios (ORs), 95% confidence intervals (95% CIs), andP-values. Results The present meta-analysis included 39 case-control studies with a total of 494 miRNAs. Only 33 miRNAs were reported in three or more studies and, of these, 18 were inconsistent in their direction of dysregulation. Two significantly dysregulated miRNAs (let-7 g and miR-155) were identified in the meta-analysis. Four miRNAs (miR-142-3p, miR-155, miR-21, and miR-34c-5p) were dysregulated in patients with T2DM, whereas five miRNAs (miR-146a, miR-199a-3p, miR-200b, miR-29b and miR-30e) were dysregulated in animal models of diabetes. In addition, two dysregulated miRNAs (miR-146a and miR-21) were highly cornea specific and heart specific. In sensitivity analysis, only miR-155 was still significantly dysregulated after removing studies with small sample sizes. Conclusions The present meta-analysis revealed that 16 stress-related miRNAs were significantly dysregulated in T2DM. MiR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b were selected as potential circulating biomarkers of T2DM. In addition, miR-146a and miR-21 were identified as potential tissue biomarkers of T2DM.
机译：许多研究背景调查小分子核糖核酸(microrna)检测2型糖尿病(2型糖尿病)。提供与压力相关的microrna的方向用作生物标记的2型糖尿病并进行了总结分析。科学,和三个中国数据库寻找病例对照microrna的分析研究关于2型糖尿病。是执行。基于不同组织和物种。灵敏度分析进行了确认鲁棒性研究。池使用ln优势比(ORs), 95%的信心间隔(CIs) 95%, andP-values。目前的荟萃分析包括39病例对照研究共有494个microrna。microrna在三个或更多的研究报道其中,18是不一致的失调的方向。microrna特异表达(let-7 g和mir - 155)在分析确定。患者2型糖尿病特异表达,而五个microrna (mir - 146 a, mir - 199 - a - 3 - p, mir - 200 b,miR-29b和miR-30e)特异表达的动物糖尿病模型。microrna (mir - 146 - a和miR-21)是高度角膜具体和心脏具体。分析,只有mir - 155仍然是显著的删除后特异表达研究小样本大小。荟萃分析显示,16与压力有关microrna明显在2型糖尿病特异表达。MiR-148b miR-223、miR-130a miR-19a miR-26b andmiR-27b被选为潜在的循环生物标志物的2型糖尿病。miR-21被确定为潜在的组织生物标志物的2型糖尿病。

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