Radiosynthesis of (123I)betaCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain.

Carpinelli A; Matarrese M; Moresco RM; Simonelli P; Todde S; Magni F; Galli-Kienle M; Fazio F

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Radiosynthesis of (123I)betaCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain.

机译：（123I）betaCIT的放射性合成，一种选择性配体，用于研究人脑中的多巴胺能和5-羟色胺能系统。

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The procedure previously reported for the radiosynthesis of [123I]betaCIT was modified in order to improve both radiochemical yield and purity of betaCIT (2beta-carbomethoxy-3beta(4-iodophenyl) tropane) to be injected for SPECT (Single Photon Emission Computed Tomography) analysis imaging. The overall procedure, involving a HPLC purification step, results in quite good and reproducible yields of a highly purified tracer.

机译：修改了先前报道的[123I] betaCIT放射性合成方法，以提高放射化学产率和要注入SPECT（单光子发射计算机断层扫描）的betaCIT（2beta-羰甲氧基-3beta（4-碘苯基）托烷）的纯度。分析成像。整个过程（包括HPLC纯化步骤）可导致高度纯化的示踪剂具有良好且可重现的产率。

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |2001年第1期|共3页
作者
Carpinelli A; Matarrese M; Moresco RM; Simonelli P; Todde S; Magni F; Galli-Kienle M; Fazio F;
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正文语种 eng
中图分类原子核物理学、高能物理学;放射医学;
关键词
Brain; Cocaine; Dopamine; Iodine Radioisotopes; Radiopharmaceuticals; Serotonin; 脑; 可卡因; 多巴胺; 碘放射性同位素; 放射性药物; 血清素; 体层摄影术; 发射型计算机; 单光子;

机译：Brain;Cocaine;Dopamine;Iodine Radioisotopes;Radiopharmaceuticals;Serotonin;脑;可卡因;多巴胺;碘放射性同位素;放射性药物;血清素;体层摄影术;发射型计算机;单光子;

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1. Radiosynthesis of (123I)betaCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain. [J] . Carpinelli A, Matarrese M, Moresco RM, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2001,第1期

机译：（123I）betaCIT的放射性合成，一种选择性配体，用于研究人脑中的多巴胺能和5-羟色胺能系统。
2. Radiosynthesis of [~(123)I]βCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain [J] . A. Carpinelli, M. Matarrese, R.M. Moresco, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2001,第1期

机译：[〜（123）I]βCIT的放射合成，它是研究人脑中多巴胺能和5-羟色胺能系统的选择性配体
3. Radiosynthesis of [I-123]beta CIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain [J] . Carpinelli A., Moresco RM., Simonelli P., Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2001,第1期

机译：放射性合成[I-123]βCIT，一种选择性配体，用于研究人脑中的多巴胺能和5-羟色胺能系统
4. Human integrin alpha_v beta_5:homology modeling and ligands docking.Implications for ligand binding selectivity [C] . Luciana Marinelli, Paolo Grieco, Axel Meyer International Peptide Symposium;European Peptide Symposium . 2005

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机译：5-羟色胺诱导的大鼠纹状体神经元c-fos和jun B基因激活中5-羟色胺能和多巴胺能系统的相互作用

Radiosynthesis of (123I)betaCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain.

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