Optimisation study of alpha-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes.

Groppi F; Bonardi ML; Birattari C; Menapace E; Abbas K; Holzwarth U; Alfarano A; Morzenti S; Zona C; Alfassi ZB

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Optimisation study of alpha-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes.

机译：用于高LET代谢放射治疗的At-211 / Po-211gα-回旋加速器生产的优化研究。

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The production of no-carrier-added (NCA) alpha-emitter (211)At/(211g)Po radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, through the (209)Bi(alpha,2n) reaction, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments at the MC-40 cyclotron of JRC-Ispra. The amount of both the gamma-emitter (210)At and its long half-lived alpha-emitting daughter (210)Po is optimised and minimised by appropriate choice of energy and energy loss of alpha particle beam. The measured excitation functions for production of the main radioisotopic impurity (210)At-->(210)Po are compared with theoretical predictions from model calculations performed at ENEA.

机译：通过（209）Bi（alpha，2n）反应以及所需的制备无载体的（NCA）α-发射体（211）At /（211g）Po放射性核素，用于高LET靶向放射治疗和免疫放射治疗通过在JRC-Ispra的MC-40回旋加速器上进行专门的辐射实验，描述了在LASA进行的湿法放射化学和放射分析质量控制。通过适当地选择能量和α粒子束的能量损失，可以优化和最小化伽玛发射体（210）At及其长半衰期的发射α的子体（210）Po的数量。将产生的主要放射性同位素杂质（210）At->（210）Po的测量激发函数与ENEA进行的模型计算得出的理论预测进行了比较。

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |2005年第6期|共11页
作者
Groppi F; Bonardi ML; Birattari C; Menapace E; Abbas K; Holzwarth U; Alfarano A; Morzenti S; Zona C; Alfassi ZB;
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正文语种 eng
中图分类特种医学;
关键词
Production; Linear Energy Transfer; radiotherapeutic; Cyclotrons; Energy; Physics; 传能线密度; 回旋加速器;

机译：Production;Linear Energy Transfer;radiotherapeutic;Cyclotrons;Energy;Physics;传能线密度;回旋加速器;

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1. Optimisation study of alpha-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes. [J] . Groppi F, Bonardi ML, Birattari C, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2005,第5a6期

机译：用于高LET代谢放射治疗的At-211 / Po-211gα-回旋加速器生产的优化研究。
2. Phase I Study of Dose-Escalated Hyperfractionated Radiotherapy (HFRT) Boost to Residual Metabolic Disease (RMD) As Defined by 18F-FDG PET/CT immediately Following Standard Chemoradiotherapy (SCRT) for Locally Advanced Esophageal Cancer (LAEC) [J] . Chen Z., Cheng N., Zhang T., International Journal of Radiation Oncology, Biology, Physics . 2019,第1Suppla期

机译：I阶段升高的高度分量放射治疗（HFRT）升压到残余代谢疾病（RMD），如18F-FDG PET / CT在标准的化学疗法（SCRT）以进行局部晚期食管癌（LAEC）
3. Excitation function for deuteron induced nuclear reactions on natural ytterbium for production of high specific activity 177g Lu in no-carrier-added form for metabolic radiotherapy. [J] . Manenti S, Groppi F, Gandini A, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2011,第1期

机译：氘在天然y上诱发氘核反应的激发功能，可产生无载体形式的高比活度177g Lu，用于代谢放疗。
4. Recent Activities on Innovative Radionuclide Production for Metabolic Radiotherapy and Pet and on Relevant Experimental and Evaluated Nuclear Data [C] . C. Birattari, M.L. Bonardi, F. Groppi, International Conference on Isotopes (5ICI) . 2005

机译：最近的新陈代谢放疗和宠物和相关实验和评估核数据的创新放射性核素生产的活动
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Optimisation study of alpha-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes.

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