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Post-elution concentration of (188)Re by an electrochemical method.

机译:通过电化学方法对(188)Re进行洗脱后浓缩。

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摘要

High specific activity (188)Re required for nuclear medicine is mostly obtained from (188)W/(188)Re generators. As the parent radionuclide (188)W is of low specific activity (<185 GBq/g), a relatively large volume of 0.9% saline is required for the elution of (188)Re. Post-elution concentration is needed in order to increase the radioactive concentration of the eluted (188)Re. An electrochemical procedure to concentrate (188)Re suitable for the preparation of radiopharmaceuticals is developed. (188)Re eluted from an alumina generator could be concentrated approximately 100 fold, and it could be used to label DMSA and HEDP with >98% yield.
机译:核医学所需的高比活(188)Re主要来自(188)W /(188)Re发生器。由于母体放射性核素(188)W的比活度较低(<185 GBq / g),因此洗脱(188)Re需要相对较大体积的0.9%盐水。为了增加洗脱的(188)Re的放射性浓度,需要洗脱后浓度。开发了一种浓缩(188)Re的电化学程序,适用于制备放射性药物。 (188)从氧化铝发生器洗脱的重金属可以浓缩约100倍,可用于标记DMSA和HEDP,收率> 98%。

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