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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >A preliminary analysis of LET effects in the dosimetry of proton beams using PRESAGE and optical CT.
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A preliminary analysis of LET effects in the dosimetry of proton beams using PRESAGE and optical CT.

机译：使用PRESAGE和光学CT对质子束剂量学中的LET效应进行初步分析。

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摘要

PRESAGE is a solid dosimeter based on a clear polyurethane matrix doped with radiochromic components (leuco dyes). On exposure to ionizing radiation a colour change is generated in the dosimeter, and hence an optical absorption or optical density change that can be read out by optical CT. The main focus of present investigations has been to investigate the possible LET dependence of PRESAGE to the dose deposited at the Bragg maxima using proton beam absorbed dose measurements, and the linearity of response of the dosimeter. Proton irradiations were performed using the proton beam facility at the Douglas Cyclotron, Clatterbridge Centre for Oncology (CCO) using a configuration that approximates the one routinely used in treatment of patients with ocular tumours. The samples were irradiated with both monoenergetic and modulated proton beams. Optical tomography measurements were carried out with our in-house CCD-based optical-CT system. Initial results for monoenergetic beams show that in PRESAGE the measured ratio of the Bragg peak dose to entrance dose is approximately 2:1 whereas the true value measured at CCO is approximately 5:1. For range-modulated proton beams, the absorbed dose close to the end of the proton range, i.e. at the Bragg peak, is underestimated by approximately 20% compared to the corresponding diode measurement. Further investigations are necessary to understand and quantify the effect of LET on PRESAGE, and to measure the uncertainties related to our optical CT.
机译：PRESAGE是基于掺杂有放射致变色成分（无色染料）的透明聚氨酯基质的固体剂量计。暴露于电离辐射后，剂量计中会发生颜色变化，因此可以通过光学CT读取光吸收率或光密度变化。当前研究的主要焦点是使用质子束吸收剂量测量来研究PRESAGE对沉积在Bragg最大值处的剂量的可能LET依赖性，以及剂量计响应的线性。使用位于Clatterbridge肿瘤学中心（Douglas Cyclotron）的道格拉斯回旋加速器（Douglas Cyclotron）的质子束设施进行的质子辐照，其配置近似于通常用于治疗眼肿瘤患者的配置。用单能和调制质子束照射样品。光学层析成像测量是使用我们基于CCD的内部光学CT系统进行的。单能光束的初步结果表明，在预测量中，布拉格峰剂量与入射剂量的比值约为2：1，而CCO的真实值约为5：1。对于距离调制的质子束，与相应的二极管测量值相比，接近质子范围末端（即布拉格峰）的吸收剂量低估了约20％。有必要进行进一步的研究，以了解和量化LET对PRESAGE的影响，并测量与我们的光学CT相关的不确定性。

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