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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Synthesis and biodistribution of a novel (99m)Tc nitrido dithiocarbamate complex containing aromatic group for cerebral imaging.
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Synthesis and biodistribution of a novel (99m)Tc nitrido dithiocarbamate complex containing aromatic group for cerebral imaging.

机译：合成和生物分布的新型（99m）Tc含芳香族基团的Nb二硫代氨基甲酸酯脑复合物。

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摘要

In the present study, the N-benzyl dithiocarbamate (BZDTC) was synthesized and radiolabeled with [(99m)TcN](2+) intermediate to form the bis(N-benzyl dithiocarbamato) nitrido technetium-99m complex [(99m)TcN(BZDTC)(2)]. The radiochemical purity of the complex was over 90% by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC). It was stable over 6h at room temperature. The partition coefficient and electrophoresis results indicated that this complex was lipophilic and neutral. Biodistribution in mice showed that the complex accumulated in the brain with high uptake. The brain uptake (ID%/g) was 1.87, 1.21 and 0.85 and the brain/blood ratio was 0.75, 1.55 and 1.12 at 5, 30 and 60min post-injection, respectively. These results suggest that this complex could be a potential brain perfusion imaging agent.
机译：在本研究中，合成了N-苄基二硫代氨基甲酸酯（BZDTC），并用[（99m）TcN]（2+）中间体进行了放射性标记，形成了双（N-苄基二硫代氨基甲酸酯）硝化ido 99m络合物[（99m）TcN（ BZDTC）（2）]。通过薄层色谱法（TLC）和高效液相色谱法（HPLC），该配合物的放射化学纯度超过90％。在室温下稳定超过6h。分配系数和电泳结果表明该络合物为亲脂性和中性的。小鼠体内的生物分布表明，该复合物在大脑中具有高吸收性。注射后5、30和60分钟的大脑摄取（ID％/ g）为1.87、1.21和0.85，脑/血比分别为0.75、1.55和1.12。这些结果表明，这种复合物可能是潜在的脑灌注显像剂。

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