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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Synthesis of a novel 99mTc nitrido radiopharmaceutical with isopropyl xanthate, showing brain uptake.
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Synthesis of a novel 99mTc nitrido radiopharmaceutical with isopropyl xanthate, showing brain uptake.

机译：异丙基黄药合成了一种新型的99mTc硝态氮放射性药物，显示出对大脑的吸收。

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摘要

In the present study, isopropyl xanthate (IPXT) ligand was labeled with the [(99m)Tc triple bond N](2+) core successfully to obtain the (99m)TcN(IPXT)(2) complex with high radiochemical purity. No decomposition of the complex at room temperature was observed over a period of 6h. Its partition coefficient indicated that it was a good lipophilic complex. The electrophoresis results showed that the complex was neutral. Biodistribution in mice demonstrated that the complex accumulated in the brain with high uptake and good retention. The brain uptake (ID%/g) was 1.95, 1.58 and 1.86 at 5-, 30- and 60-min post-injection, respectively. As compared with other reported (99m)TcN-xanthates, the (99m)TcN(IPXT)(2) complex showed higher brain uptake and better brain retention, suggesting potential usefulness of the complex as a brain perfusion imaging agent.
机译：在本研究中，成功​​地用[（99m）Tc三键N]（2+）核心标记了异丙基黄药（IPXT）配体，从而获得了具有高放射化学纯度的（99m）TcN（IPXT）（2）复合物。在6小时内未观察到在室温下复合物的分解。其分配系数表明它是一种良好的亲脂性复合物。电泳结果表明该络合物是中性的。小鼠体内的生物分布表明，该复合物以高吸收和良好的滞留性在大脑中积累。注射后5分钟，30分钟和60分钟时的大脑摄取（ID％/ g）分别为1.95、1.58和1.86。与其他报道的（99m）TcN-黄药相比，（99m）TcN（IPXT）（2）复合物显示出更高的脑摄取和更好的脑滞留性，表明该复合物作为脑灌注显像剂的潜在用途。

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