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首页> 外文期刊>Ophthalmic surgery, lasers & imaging: the official journal of the International Society for Imaging in the Eye >Femtosecond laser photodisruption of porcine anterior chamber angle: an ex vivo study.
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Femtosecond laser photodisruption of porcine anterior chamber angle: an ex vivo study.

机译：飞秒激光光剥离的猪前房角:体外研究。

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BACKGROUND AND OBJECTIVE: The femtosecond laser is a promising tool for the micromachining of biological tissues. The current study investigated the feasibility of noninvasive glaucoma therapy by femtosecond laser ablation in enucleated porcine eyes by delivering the laser energy through a gonioscopic lens. MATERIALS AND METHODS: Freshly enucleated porcine eyes were kept in Optisol GS solution (Bausch & Lomb, Rochester, NY) at 4 degrees C for up to 48 hours. Photodisruption was attempted at the peripheral inner surface of the cornea using a gonioscopic lens and a custom femtosecond laser ablation system. Femtosecond laser ablation was performed using a Ti:Sapphire laser (800-nm wavelength) focused with a 0.15 numerical aperture lens. The laser treatment process was recorded by real time video and the lesions were examined histologically. RESULTS: During laser surgery, bubble formation was observed and appeared to be positively related to laser energy and exposure time. When examined histologically, areas of ablation were consistently observed at the peripheral inner surface of the cornea. The extent of the lesion increased nonlinearly with both pulse energy and exposure time, showing saturation at high energy and long times. For a given energy dose, fewer pulses of high energy were more effective than many low energy pulses. CONCLUSION: The current study demonstrates that laser ablation at the anterior chamber angle is feasible by a femtosecond laser ablation system using a gonioscopic lens in ex vivo eyes. The results indicate the potential of a novel noninvasive glaucoma laser therapy.
机译：背景和目的:飞秒激光一个有前途的微加工的工具生物组织。研究非侵入性的可行性青光眼治疗通过飞秒激光烧蚀阐明猪眼睛提供激光能量通过gonioscopic镜头。方法:新鲜无核的猪的眼睛在前GS的解决方案(博士伦,罗彻斯特,纽约)在4摄氏度48小时。光剥离在外围未遂使用gonioscopic角膜的内表面镜头和一个定制的飞秒激光烧蚀系统。使用钛蓝宝石激光器(800 nm波长)聚焦透镜数值孔径0.15。激光治疗过程被实时记录视频和病变的检查组织学检查。观察泡沫的形成,似乎积极与激光能量和接触时间。消融被观察到周边角膜的内表面。病变的严重程度而非线性增加脉冲能量和曝光时间,显示在高能源和长时间饱和。鉴于能源剂量,减少高能脉冲是更有效的比许多低能量脉冲。结论:目前研究表明激光消融在前房角飞秒激光烧蚀系统可行在体外使用gonioscopic镜头的眼睛。结果表明潜在的一部小说非侵入性青光眼激光治疗。

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