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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Polymorphonuclear leukocytes increase the adhesion of circulating tumor cells to microvascular endothelium.
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Polymorphonuclear leukocytes increase the adhesion of circulating tumor cells to microvascular endothelium.

机译：多形核白细胞增加循环肿瘤细胞对微血管内皮的粘附。

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摘要

BACKGROUND: Reactive oxygen species (ROS) released from activated polymorphonuclear leukocytes (PMN) during surgery may play a crucial role in the enhanced distant tumor recurrence after surgical trauma. MATERIALS AND METHODS: The effect of PMN on the adhesion of the human colon carcinoma cells HT29, Caco2 and the pancreatic carcinoma cells PanC1 and BxPC3 to microvascular endothelium (MEC) was studied in a reproducible human in vitro model. RESULTS: Pre-incubation of MEC with tissue plasminogen activator (TPA)-activated PMN resulted in more than 200% increase of tumor cell adhesion to MEC compared to control (p < 0.01). Exposure of MEC to TPA or non-activated PMN did not significantly affect adhesion. Addition of the antioxidant enzymes superoxide dismutase or catalase significantly decreased tumor cell adhesion to MEC exposed to PMN. CONCLUSION: These results demonstrate that activated PMN promote tumor cell adhesion to the microvascular wall by production of ROS. This indicates that in tackling the ROS production, preventing tumor recurrence at distant sites, might be feasible.
机译：背景：手术期间从活化的多形核白细胞（PMN）释放的活性氧（ROS）可能在手术创伤后远处肿瘤复发的增强中起关键作用。材料与方法：在可复制的人体外模型中研究了PMN对人结肠癌细胞HT29，Caco2以及胰腺癌细胞PanC1和BxPC3与微血管内皮（MEC）的粘附作用。结果：与组织纤溶酶原激活物（TPA）激活的PMN一起预孵育MEC，与对照相比，肿瘤细胞对MEC的粘附增加了200％以上（p <0.01）。将MEC暴露于TPA或未活化的PMN不会显着影响粘附。加入抗氧化酶超氧化物歧化酶或过氧化氢酶可显着降低肿瘤细胞对暴露于PMN的MEC的粘附力。结论：这些结果表明，活化的PMN通过产生ROS促进肿瘤细胞对微血管壁的粘附。这表明在解决ROS产生中，防止远处肿瘤复发可能是可行的。

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