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首页> 外文期刊>Psychology of addictive behaviors >Changes in the Elimination and Resurgence of Alcohol-Maintained Behavior in Rats and the Effects of Naltrexone
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Changes in the Elimination and Resurgence of Alcohol-Maintained Behavior in Rats and the Effects of Naltrexone

机译：的消除和复兴的变化在老鼠和Alcohol-Maintained行为环丙甲羟二羟吗啡酮的影响

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Resurgence may be a mechanism of relapse in alcohol use disorder patients upon discharge from treatment as part of an abuse-treatment-relapse cycle. Adjunctive pharmacotherapies may be a means to facilitate behavioral treatments and block resurgence. Experiments were conducted using a model of alcohol self-administration to assess the repeatability of the elimination and resurgence of alcohol-maintained behavior and the effects of naltrexone. Experiments had three phases. In Phase 1, behavior was maintained by oral alcohol under a fixed-ratio schedule. In Phase 2, behavior was extinguished via condensed milk delivery under a differential-reinforcement-of-other-behavior (DRO) schedule. In Phase 3, the DRO schedule was eliminated. In Experiment 1, this 3-phase cycle was replicated 4 times. Across replications, response rates and dose of alcohol consumed did not differ in Phase 1, alcohol-maintained behavior was eliminated more rapidly in Phase 2, and the resurgence effect was generally stable in Phase 3. In Experiment 2, naltrexone was administered in Phase 2, Phase 3, or both Phases 2 and 3, to separate groups of rats. Naltrexone facilitated the elimination of alcohol-maintained behavior in Phase 2 and, the resurgence of alcohol-maintained behavior was reduced only for those rats that received naltrexone in both phases. Together, these experiments demonstrate that the resurgence of alcohol-maintained behavior is replicable within-subjects and, further, resurgence of alcohol-maintained behavior may he a useful model to evaluate pharmacological interventions to facilitate behavioral treatments and reduce the likelihood of relapse. Results with naltrexone support the use of medication-assisted therapy approaches to reduce relapse risk in patients.
机译：复苏可能复发的机制酒精使用障碍的患者在出院治疗作为abuse-treatment-relapse的一部分周期。促进行为的治疗方法和手段阻碍复苏。使用酒精自治制度的典范评估消除的可重复性alcohol-maintained行为和复兴环丙甲羟二羟吗啡酮的影响。阶段。口服酒精固定比率的时间表。第二阶段,通过凝聚行为被扑灭牛奶下交货differential-reinforcement-of-other-behavior(滴)计划。消除。重复4次。响应率和剂量的酒精消费不是在阶段1不同,alcohol-maintained行为更加迅速地在第二阶段被淘汰,和复苏效果总体上是稳定的阶段3。管理在第二阶段、第三阶段或阶段2和3,分离大鼠组。促进alcohol-maintained的消除在第二阶段的行为,死灰复燃alcohol-maintained行为只是为了减少收到纳曲酮的老鼠阶段。alcohol-maintained的复苏行为是可复制的受试,此外,alcohol-maintained再度抬头行为可能他一个有用的评估模型药理干预促进行为治疗和减少的可能性的复发。使用进行药物治疗——辅助治疗方法降低复发风险的患者。

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