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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Analysis of the TEL protein during tumour angiogenesis.
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Analysis of the TEL protein during tumour angiogenesis.

机译：肿瘤血管生成过程中TEL蛋白的分析。

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摘要

It has been proposed that breast cancer follows a programmed course of development that leads to an invasive phenotype that is associated with an increase in angiogenesis. Angiogenesis is a multistage process that requires, at its early stages, proliferation of endothelial cells, the break-down of their basement membranes, and their subsequent migration and organisation into new bud-like vascular structures. The regulation of endothelial cell proliferation and migration during angiogenesis involves the ETS family of transcription factors. The TEL gene is a member of the ETS family and may play a role in vessel formation. Vascular endothelial growth factor (VEGF) is a specific growth factor in new vessel formation and in this study its regulatory effects on TEL protein phosphorylation are detailed. The TEL protein is found to be expressed during early endothelial cell tube formation in vitro. However, smaller vessels in either tumour or ovarian angiogenesis did not express the transcription factor; only the larger mature vessels were positive. Interestingly, TEL protein expression was lost in the invasive breast carcinoma studied, whilst in normal breast tissue, hyperplasia and ductal carcinoma in-situ, TEL protein expression was seen. The loss of expression of TEL protein in invasive mammary gland carcinoma may be an important factor in the pathogenesis of breast carcinoma.
机译：已经提出乳腺癌遵循程序化的发展过程，该过程导致与血管生成增加有关的侵入性表型。血管生成是一个多阶段的过程，在早期需要内皮细胞的增殖，其基膜的分解以及随后的迁移和组织成为新的芽状血管结构。血管生成过程中内皮细胞增殖和迁移的调控涉及ETS转录因子家族。 TEL基因是ETS家族的成员，可能在血管形成中起作用。血管内皮生长因子（VEGF）是新血管形成中的特定生长因子，本研究详细介绍了其对TEL蛋白磷酸化的调节作用。发现TEL蛋白在体外早期内皮细胞管形成过程中表达。然而，在肿瘤或卵巢血管生成中较小的血管不表达转录因子。只有较大的成熟血管为阳性。有趣的是，在研究的浸润性乳腺癌中，TEL蛋白表达丢失，而在正常乳腺组织，增生和导管癌中，TEL蛋白表达可见。浸润性乳腺癌中TEL蛋白表达的丧失可能是乳腺癌发病机制中的重要因素。

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